Role of Integrins in Sperm Activation and Fertilization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F21%3A00549068" target="_blank" >RIV/86652036:_____/21:00549068 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/21/11809" target="_blank" >https://www.mdpi.com/1422-0067/22/21/11809</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms222111809" target="_blank" >10.3390/ijms222111809</a>
Alternative languages
Result language
angličtina
Original language name
Role of Integrins in Sperm Activation and Fertilization
Original language description
In mammals, integrins are heterodimeric transmembrane glycoproteins that represent a large group of cell adhesion receptors involved in cell-cell, cell-extracellular matrix, and cell-pathogen interactions. Integrin receptors are an important part of signalization pathways and have an ability to transmit signals into and out of cells and participate in cell activation. In addition to somatic cells, integrins have also been detected on germ cells and are known to play a crucial role in complex gamete-specific physiological events, resulting in sperm-oocyte fusion. The main aim of this review is to summarize the current knowledge on integrins in reproduction and deliver novel perspectives and graphical interpretations presenting integrin subunits localization and their dynamic relocation during sperm maturation in comparison to the oocyte. A significant part of this review is devoted to discussing the existing view of the role of integrins during sperm migration through the female reproductive tract, oviductal reservoir formation, sperm maturation processes ensuing capacitation and the acrosome reaction, and their direct and indirect involvement in gamete membrane adhesion and fusion leading to fertilization.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
21
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
11809
UT code for WoS article
000721178800001
EID of the result in the Scopus database
2-s2.0-85118112349