Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00557420" target="_blank" >RIV/86652036:_____/22:00557420 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S156713482200051X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S156713482200051X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.meegid.2022.105254" target="_blank" >10.1016/j.meegid.2022.105254</a>
Alternative languages
Result language
angličtina
Original language name
Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage
Original language description
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), accountable for causing the coronavirus diseases 2019 (COVID-19), is already declared as a pandemic disease globally. Like previously reported SARS-CoV strain, the novel SARS-CoV-2 also initiates the viral pathogenesis via docking viral spike-protein with the membranal angiotensin-converting enzyme 2 (ACE2) a receptor on variety of cells in the human body. Therefore, COVID19 is broadly characterized as a disease that targets multiple organs, particularly causing acute complications via organ-specific pathogenesis accompanied by destruction of ACE2(+) cells, including alveolus, cardiac microvasculature, endothelium, and glomerulus. Under such circumstances, the high expression of ACE2 in predisposing individuals associated with anomalous production of the renin-angiotensin system (RAS) may promote enhanced viral load in COVID-19, which comparatively triggers excessive apoptosis. Furthermore, multi-organ injuries were found linked to altered ACE2 expression and inequality between the ACE2/angiotensin-(1-7)/mitochondrial Ang system (MAS) and renin-angiotensin-system (RAS) in COVID-19 patients. However, the exact pathogenesis of multi-organ damage in COVID-19 is still obscure, but several perspectives have been postulated, involving altered ACE2 expression linked with direct/indirect damages by the virus-induced immune responses, such as cytokinin storm. Thus, insights into the invasion of a virus with respect to ACE2 expression site can be helpful to simulate or understand the possible complications in the targeted organ during viral infection. Hence, this review summarizes the multiple organs invasion by SARS CoV-2 linked with ACE2 expression and their consequences, which can be helpful in the management of the COVID-19 pathogenesis under life-threatening conditions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/EF16_025%2F0007397" target="_blank" >EF16_025/0007397: Recombinant Biotechnology and Immunotherapy Centre</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Infection, Genetics and Evolution
ISSN
1567-1348
e-ISSN
1567-7257
Volume of the periodical
99
Issue of the periodical within the volume
APR 2022
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
21
Pages from-to
105254
UT code for WoS article
000790733800006
EID of the result in the Scopus database
2-s2.0-85125263307