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Kinetic Study of 17 alpha-Estradiol Mechanism during Rat Sperm Capacitation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F22%3A00559402" target="_blank" >RIV/86652036:_____/22:00559402 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.mdpi.com/1420-3049/27/13/4092" target="_blank" >https://www.mdpi.com/1420-3049/27/13/4092</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/molecules27134092" target="_blank" >10.3390/molecules27134092</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Kinetic Study of 17 alpha-Estradiol Mechanism during Rat Sperm Capacitation

  • Original language description

    17 alpha-Estradiol (alpha E2) is a natural diastereoisomer of 17 beta-estradiol (E2). It is well known that alpha E2 can bind to estrogen receptors. However, its biological activity is less than that of E2 and is species and tissue specific. The goal of our study was to propose the mechanism of alpha E2 hormonal response in rat sperm during their capacitation in vitro and compare it with a previously studied mouse model. Concentration changes in externally added alpha E2 during capacitation of rat sperm were monitored by the high-performance liquid chromatographic method with tandem mass spectrometric detection (HPLC-MS/MS). The calculated values of relative concentrations B-t were subjected to kinetic analysis. The findings indicated that alpha E2 in rat sperm did not trigger autocatalytic reaction, in contrast to the mouse sperm, and that the initiation of the hormone penetration through the sperm plasma membrane was substantially faster in rats.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecules

  • ISSN

    1420-3049

  • e-ISSN

    1420-3049

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    13

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    9

  • Pages from-to

    4092

  • UT code for WoS article

    000824750800001

  • EID of the result in the Scopus database

    2-s2.0-85133232087