Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F23%3A00576796" target="_blank" >RIV/86652036:_____/23:00576796 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/anie.202214659" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/anie.202214659</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.202214659" target="_blank" >10.1002/anie.202214659</a>
Alternative languages
Result language
angličtina
Original language name
Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers
Original language description
Chemical immunotherapeutic strategies including Antibody Recruiting Molecules (ARMs bivalent small molecules containing an antibody-binding domain (ABD) and a target-binding domain (TBD)) direct immune-mediated clearance of diseased cells. Anti-cancer ARM function relies on high tumor antigen valency, limiting function against lower antigen expressing tumors. To address this limitation, we report a tunable multivalent immune recruitment (MIR) platform to amplify/stabilize antibody recruitment to cells with lower antigen valencies. An initial set of polymeric ARMs (pARMs) were synthesized and screened to evaluate ABD/TBD copy number, ratio, and steric occlusion on specific immune induction. Most pARMs demonstrated simultaneous high avidity binding to anti-dinitrophenyl antibodies and prostate-specific membrane antigens on prostate cancer. Optimized pARMs mediated enhanced anti-cancer immune function against lower antigen expressing target cells compared to an analogous ARM.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
1521-3773
Volume of the periodical
JAN 2023
Issue of the periodical within the volume
2023-02-12
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
—
UT code for WoS article
000919689600001
EID of the result in the Scopus database
2-s2.0-85146724725