Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F24%3A00584812" target="_blank" >RIV/86652036:_____/24:00584812 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43926666 RIV/00216208:11140/24:10475509 RIV/00064173:_____/24:43926666
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2589004224002657?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2589004224002657?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2024.109044" target="_blank" >10.1016/j.isci.2024.109044</a>

Result language
angličtina
Original language name
Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma
Original language description
Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the most appropriate drugs and therapeutic regimens is the most promising way to improve the treatment outcomes of the patients. This study aimed to compare (1) in vitro efficacy and (2) in vivo antitumor effects of conventional paclitaxel and the newly synthesized second (SB-T-1216) and third (SB-T-121605 and SB-T-121606) generation taxanes in KRAS wild type BxPC-3 and more aggressive KRAS G12V mutated Paca-44 pancreatic cancer cell line models. In vitro, paclitaxel efficacy was 27.6 G 1.7 nM, while SB-Ts showed 1.7-7.4 times higher efficacy. Incorporation of SB-T121605 and SB-T-121606 into in vivo therapeutic regimens containing paclitaxel was effective in suppressing tumor growth in Paca-44 tumorbearing mice at small doses (%3 mg/kg). SB-T-121605 and SB-T121606 in combination with paclitaxel are promising candidates for the next phase of preclinical testing.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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