Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F25%3A00619834" target="_blank" >RIV/86652036:_____/25:00619834 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/25:00085580 RIV/00216208:11110/25:10498988 RIV/00216208:11310/25:10498988 RIV/60461373:22330/25:43931752
Result on the web
<a href="https://www.nature.com/articles/s41420-025-02510-z#ethics" target="_blank" >https://www.nature.com/articles/s41420-025-02510-z#ethics</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41420-025-02510-z" target="_blank" >10.1038/s41420-025-02510-z</a>
Alternative languages
Result language
angličtina
Original language name
Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention
Original language description
The article examines the role of adenine nucleotide translocator 2 (ANT2) in regulating mitochondrial functions and the survival of cancer cells, with a particular focus on pancreatic ductal adenocarcinoma (PDAC). The study shows that ANT2 helps maintain mitochondrial integrity even when oxidative phosphorylation (OXPHOS) is limited, thereby supporting tumor cell growth and resistance to cell death. Experiments involving ANT2 inhibition (both pharmacologically and using shRNA) led to reduced proliferation of PDAC cells and slower tumor growth in vivo. Combined inhibition of ANT2 and OXPHOS (using the compound MitoTam) produced a synergistic effect, significantly suppressing tumor growth. The study therefore highlights the potential of ANT2 as a therapeutic target and provides a foundation for the development of new, more selective inhibitors that could be used in the treatment of PDAC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Death Discovery
ISSN
2058-7716
e-ISSN
2058-7716
Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
225
UT code for WoS article
001484399800001
EID of the result in the Scopus database
2-s2.0-105004471214