Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F25%3A00636826" target="_blank" >RIV/86652036:_____/25:00636826 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10499962 RIV/00023001:_____/25:00085694 RIV/60461373:22330/25:43931588 RIV/00064165:_____/25:10499962
Result on the web
<a href="https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1622107/full" target="_blank" >https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1622107/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2025.1622107" target="_blank" >10.3389/fcell.2025.1622107</a>

Result language
angličtina
Original language name
Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?
Original language description
Aging is characterized by gradual deterioration of organ or tissue function and its ability to maintain homeostasis of the different physiological processes. This leads to the development of structural and functional alterations accompanied by an increased risk for diverse pathologies. Cellular senescence is a controlled biological process that could contribute to the development of many age-related diseases and related metabolic dysfunctions. Two major chronic diseases associated with premature accumulation of senescent cells that impose an enormous burden on global health systems are obesity and type 2 diabetes mellitus with its related complications. The purpose of this review is to highlight the links between aging, obesity, and type 2 diabetes mellitus, focusing on the role of cellular senescence in disease development and progression. Additionally, this review will discuss the potential of targeting cellular senescence as a promising therapeutic strategy for managing these interrelated diseases, therefore offering a novel approach to prevention and treatment.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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