Targeting Mitochondrial Integrity as a New Senolytic Strategy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F25%3A00647613" target="_blank" >RIV/86652036:_____/25:00647613 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/25:00085900 RIV/00216208:11310/25:10506954 RIV/60461373:22330/25:43931476
Result on the web
<a href="https://www.aginganddisease.org/EN/10.14336/AD.2024.1100" target="_blank" >https://www.aginganddisease.org/EN/10.14336/AD.2024.1100</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14336/AD.2024.1100" target="_blank" >10.14336/AD.2024.1100</a>
Alternative languages
Result language
angličtina
Original language name
Targeting Mitochondrial Integrity as a New Senolytic Strategy
Original language description
Aging, characterized by accumulation of senescent cells, is a driving factor of various age-related diseases. These conditions pose significant health risks globally due to their increasing prevalence and serious complications. Reduction of senescent cells therefore represents a promising strategy promoting healthy aging. Here we demonstrate that targeting tamoxifen to mitochondria via triphenyl and tricyclohexyl phosphine selectively eliminates senescent cells. Our findings show a complex effect of mitochondrially targeted tamoxifen on mitochondrial function and integrity of senescent cells, including inhibition of oxidative phosphorylation and activity of respiratory complex IV. These changes result in activation of ferroptosis as the major mode of cell death, which results in rejuvenation of tissues. Targeting mitochondria of senescent cells represents a general senolytic strategy and may extend the healthspan and improve the quality of life in aging populations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30227 - Geriatrics and gerontology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aging and Disease
ISSN
2152-5250
e-ISSN
2152-5250
Volume of the periodical
16
Issue of the periodical within the volume
FEB 2025
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
3638-3648
UT code for WoS article
001423770000001
EID of the result in the Scopus database
2-s2.0-105024112923