Relay feedback oscillator design for modeling circadian rhythms in cyanobacteria

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F12%3A00482418" target="_blank" >RIV/86652079:_____/12:00482418 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21220/11:00194392
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Relay feedback oscillator design for modeling circadian rhythms in cyanobacteria
Original language description
The paper introduces a relay feedback oscillator for modeling circadian rhythms in cyanobacteria. The relay feedback oscillator is equipped with low pass filter F(j omega), hysteresis-type relay and negative feedback. This negative feedback represents an autoregulatory mechanism of the circadian clock and the notion of this autoregulatory mechanism is based on the well-known Goodwin biochemical oscillator [1]. The relay is responsible for the mediation of both the activation and degradation of oscillator state variables (protein concentrations) and in this way the pacemaker is constituted. Later on, low pass filter poles are identified for the purpose of modeling auto-oscillations with the free running period of 24h and the method of the pole identification consists in an ultimate frequency test providing stability margin of a single-loop composed of the filter and the relay in the feedback. Next, a relay output / input ratio of amplitudes and hysteresis are found out by the graphical test of the single-loop on the stability margin which is carried out in Bode graph. Finally, the output correspondence of relay feedback oscillator model with Miyoshi oscillator [2] is provided because the Miyoshi oscillator is well recognized among biochemical oscillators for species of cyanobacteria.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2011
ISBN
978-0-7918-5488-4
ISSN
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e-ISSN
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Number of pages
8
Pages from-to
549-556
Publisher name
ASME
Place of publication
Denver, Colorado
Event location
Denver
Event date
Nov 11, 2011
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000324505000076

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