Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F20%3A00536338" target="_blank" >RIV/86652079:_____/20:00536338 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/20:00117745
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2020.104298" target="_blank" >10.1016/j.bioorg.2020.104298</a>
Alternative languages
Result language
angličtina
Original language name
Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Original language description
Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
NOV
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
104298
UT code for WoS article
000592397400007
EID of the result in the Scopus database
2-s2.0-85091969421