Investigating the phytotoxic effects of binary mixtures of diclofenac and paracetamol on duckweed synergistic or antagonistic interaction?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652079%3A_____%2F25%3A00642523" target="_blank" >RIV/86652079:_____/25:00642523 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/25:00142814

Result on the web

<a href="https://www.scopus.com/pages/publications/105019508850?origin=resultslist" target="_blank" >https://www.scopus.com/pages/publications/105019508850?origin=resultslist</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2025.127295" target="_blank" >10.1016/j.envpol.2025.127295</a>

Result language

angličtina

Original language name

Investigating the phytotoxic effects of binary mixtures of diclofenac and paracetamol on duckweed synergistic or antagonistic interaction?

Original language description

Mixtures of emerging aquatic contaminants, like diclofenac (DCF) and paracetamol (PCT) commonly occurring in the environment, can exhibit combination effects. Accumulation of drugs in duckweed plants exposed for seven days to DCF + PCT mixtures was similar to that under individual drugs (both 0.2, 2, and 20 mg/L). But the nature of drug interaction in mixtures was ambiguous, even though the toxic impact of DCF was more substantial than that of PCT. Mixtures with a DCF-to-PCT ratio of 1:1 exhibited a synergistic interaction manifested by a decrease (up to 90 %) in plant number, especially in mixtures DCF 2 + PCT 2 and DCF 20 + PCT 20 mg/L. In mixtures with unequal ratios (1:10 or 1:100 with a predominance of DCF or PCT), their interaction attenuated with time to additive or even antagonistic. This finding (shift from synergistic to additive interaction) was supported even by changes in the plants' dry weight, leaf area, or photosynthetic pigment content. Similarly, a negligible decrease in photosynthetic performance in plants exposed to the mixtures with unequal ratios supported the mitigation of the drug mixture effect. Both individual drugs and their mixtures of 2 and 20 mg/L elevated the production of reactive oxygen species. The antioxidant defence mechanism activity was elevated already by low drug doses (0.2 and 2 mg/L), and the highest contamination (20 mg/L) led to its decrease. Utilizing the number of plants parameter showed that the nature of drug interaction in the mixture is fluctuating, and the causal factors include the ratio of mixture component concentrations and the length of the exposure period.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

<a href="/en/project/QL24010115" target="_blank" >QL24010115: Innovative production of special crops as food sources with high dietary value</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Pollution

ISSN

0269-7491

e-ISSN

1873-6424

Volume of the periodical

387

Issue of the periodical within the volume

Dec.

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

127295

UT code for WoS article

001606241200001

EID of the result in the Scopus database

2-s2.0-105019508850