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Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons
and intraneuronal neurofibrillary tangles. These tangles mainly consist of hyperphosphorylated tau protein. As it induces tau hyperphosphorylation in vitro and in vivo liraglutide and palm(11)-PrRP31 attenuated
Neurosciences (including psychophysiology)
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy
, and tau hyperphosphorylation, both hallmarks of AD. The central anorexigenic effects mice overexpressing mutated human tau, a model of AD-like tau pathology. Seven of palm(11)-PrRP31-treated THY-Tau22 mice, t...
Neurosciences (including psychophysiology)
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
An identification of MARK inhibitors using high throughput MALDI-TOF mass spectrometry
in pathological hyperphosphorylation of tau protein. Hyperphosphorylated tau has decreased hyperphosphorylation of tau. It has been found that Ser(262) is phosphorylated by MARK4, which, and micr...
Biochemistry and molecular biology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Anorexigenic Lipopeptides Ameliorate Central Insulin Signaling and Attenuate Tau Phosphorylation in Hippocampi of Mice with Monosodium Glutamate-Induced Obesity
of neurofibrillary tangles, which contain an abnormally hyperphosphorylated tau protein. This study aimed to determine whether potential tau hyperphosphorylation could increased tau phosphorylation at Ser...
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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HIF-1α is a "brake" in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells
cleavage of amyloid precursor protein (APP) and hyperphosphorylation of tau (P-tau and P-tau formation in BV2 cells and determined the underlying roles of HIF-1α and P-tau. Additionally, HIF-1α acted as a...
Neurosciences (including psychophysiology)
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Hyperphosphorylation of cytoskeletal proteins in neurodegenerative diseases. Alzeimer`s disease
Alzheimer`s disease (AD) represents the most common neurodegenerative disease and cause of dementia in the elderly.
FE - Ostatní obory vnitřního lékařství
- 2002 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model
formation, microglial activation, and tau hyperphosphorylation in the brainstem of fibrillary aggregates composed of pathological tau protein. Although neuroinflammation is frequently observed in conjunction with tau
Neurosciences (including psychophysiology)
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer’s disease
in hyperphosphorylation of tau makes them potential druggable target for AD therapy. Despite patients. Microtubule affinity-regulating kinases (MARKs) regulate tau-microtubule......
Oncology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats
) in the hippocampi of the fa/fa rats. Furthermore, the hyperphosphorylation of Tau Ser396 alone and both Tau Ser396 and Thr231 was significantly augmented by aging and obesityBackground: Insulin signaling and Tau ...
CE - Biochemie
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Early but not late conformational changes of tau in association with ubiquitination of neurofibrillary pathology in Alzheimer’s disease brains
In Alzheimer's disease, tau protein undergoes post-translational modifications including hyperphosphorylation and truncation, which promotes two major with the development of the disease, tau ubiquitination was previou...
Neurosciences (including psychophysiology)
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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