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Ancient brothers of the human p53 tumour suppressor
Ancient brothers of the human p53 tumour suppressor, the evolution study...
Biochemistry and molecular biology
- 2021 •
- O
Rok uplatnění
O - Ostatní výsledky
New monoclonal antibodies recognizing the p53 tumour suppressor protein homologue p73
The p53 tumour suppressor gene is the most frequent target for genetic alterations in human tumours (Nigro et al., 1989; Hollstein et al., 1991) and encodes a nuclear phosphoprotein which plays a key role in cell-cycle regu...
FD - Onkologie a hematologie
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The mechanism of action of the tumour suppressor gene PTEN
Intracellular levels of phosphorylation are regulated by the coordinated action of protein kinases and phosphatases.
FD - Onkologie a hematologie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Antimutagenic nad cytoprotective effects of amifostine: the role of p53
The article summarizes the information available on the antimutagenic and cytoprotective effects of amifostine and its effects also on the activity of the p53 tumour suppressor....
EB - Genetika a molekulární biologie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Influence of tumour suppressor PTEN on cell cycle and apoptosis in prostate cancer cell lines
PTEN is one of the most frequently mutated genes. The frequency of its mutations is approaching aberations detected in tumor supressor p53.
FD - Onkologie a hematologie
- 2003 •
- D
Rok uplatnění
D - Stať ve sborníku
Tumour Suppressor PTEN Regulates Cell Cycle and Protein Kinase B/Akt Pathway in Breast Cancer Cells
Background: PTEN is a tumour suppressor protein with phosphatase activity frequently altered in several types of human cancers. Materials and Methods: The PTEN effect was studied on the cell cycle (by bromdeoxyuridine incorporation)...
FD - Onkologie a hematologie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Importance of Tumour Suppressor Gene Methylation in Sinonasal Carcinomas
Epigenetic changes are considered to be a frequent event. during tomour development. Hypermethylation of promoter CpG; islands represents an alternative mechanism for inactivation of tumour suppressor genes, DNA repair genes, cell c...
FD - Onkologie a hematologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
MEG3: A novel long noncoding potentially tumour-suppressing RNA in meningiomas (Review)
as well as recurrent tumours. It has long been supposed that chromosome 14q32 contains a tumour suppressor gene. However, the identity of the potential 14q32 tumour suppressor remained elusive until the M...
FH - Neurologie, neurochirurgie, neurovědy
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The influence of tumour immunity suppressors on the effector stage of human and animal lymphokine - activated killer cells.
Annotation not available...
EB - Genetika a molekulární biologie
- 1993 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes
Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of fi...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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