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Glycopolymer Inhibitors of Galectin-3 Suppress the Markers of Tissue Remodeling in Pulmonary Hypertension
hypertension. Here, we present the synthesis of novel hydrophilic glycopolymer inhibitors interferometry revealed a high binding affinity of these glycopolymers to Gal-3 muscle cells, the most potent glycopolymer 18 (Lac-h...
Organic chemistry
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Glycopolymer, a method of its preparation and its use as a medicine
The solution concerns multivalent glycopolymers based on HPMA polymers (copolymers and homopolymers) with saccharide structures containing a terminal monosaccharide in the galacto-configuration, which are effective as galectin inhibitors. Th...
Polymer science
- 2023 •
- P •
- Link
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P - Patent
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Glycopolymers Decorated with 3-O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3
contents. Glycopolymers with a higher content of glycomimetic exhibited a higher cultures. These glycopolymers inhibited Gal-3-induced processes in cancer cells. The cyanophenyl-substituted glycopolymer exhibited the stron...
Biochemistry and molecular biology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Glycopolymer, a method of its preparation and its use as a medicine
A glycopolymer consisting of HPMA polymers with a content of from 0.5 to 25% mol. of structural units of formula I and optionally end groups having a formula of–S-succinimide- (CH2)r-Linker-Substituted saccharide or– C(CN)(CH3)-(C1-C4 alkyle...
Polymer science
- 2023 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Glycopolymer, a method of its preparation and its use as a medicine
A glycopolymer consisting of HPMA polymers with a content of from 0.5 to 25% mol. of structural units of formula I and optionally end groups having a formula of–S-succinimide- (CH2)r-Linker-Substituted saccharide or– C(CN)(CH3)-(C1-C4 alkyle...
Polymer science
- 2023 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Glycopolymers for efficient inhibition of galectin-3: in vitro proof of efficacy using suppression of T lymphocyte apoptosis and tumor cell migration
synthesized multivalent glycopolymer inhibitors with a high potential to target conditions showed that the glycopolymers strongly inhibited Gal-3-induced apoptosis of T the enhanced permeability and retention effect, nominate the <...
Polymer science
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Glycan-decorated HPMA copolymers as high-affinity lectin ligands
cycloaddition. The soluble, biocompatible, and structurally flexible synthetic glycopolymers glycopolymers among the best WGA ligands reported to date. This study demonstrates the targeting potential of these glycopolymers...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Exploitation of a Library of alfa-Galactosidases for the Synthesis of Building Blocks for Glycopolymers.
In addition to selective midifications of natural macromolecules, enzymatic and chemo-enzymatic syntheses of polymers have been described in the literature....
EE - Mikrobiologie, virologie
- 2002 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
High-affinity N-(2-hydroxypropyl)methacrylamide copolymers with tailored N-acetyllactosamine presentation discriminate between galectins
-hydroxypropyl)methacrylamide (HPMA)-based glycopolymers with varying LacNAc amounts in glycopolymer) prepared by enzymatic synthesis under catalysis by β-galactosidase from preference based just on the structure of a multivalent
Polymer science
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Exploitation of a Library of alfa-Galactosidases for the Sysnthesis of Building Blocks for Glycopolymers.
After screening a library of fugal alfa-galactosidases for the synthesis of functionalized alkyl alfa-D-galactopyranosides, four enzymes proved to be suitable for these biotransformations....
EE - Mikrobiologie, virologie
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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