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The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients
OBJECTIVE: The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to ide...
FK - Gynekologie a porodnictví
- 2012 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The role of FLT3 mutations in the pathogenesis of acute myeloid leukemia
FLT3 (FMS-like tyrosine kinase 3) is a tyrosine kinase receptor expressed by early hematopoietic progenitor cells and is essential fot its normal development and proliferation. Activating...
FD - Onkologie a hematologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Gemtuzumab ozogamicin plus midostaurin in conjunction with standard intensive therapy for FLT3-mutated acute myeloid leukemia patients – Czech center experience
immunoconjugate, gemtuzumab ozogamicin (GO), and an inhibitor of mutant FMS-like tyrosine kinase 3 (FLT3), midostaurin. Our study's major strength is its unique focus......
Hematology
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Life threatening hypoglycaemia in a child with infantile myofibromatosis
endothelial growth factor receptors (VEGFR-1, VEGFR-2 and VEGFR-3), stem cell factor receptor (Kit) like tyrosine kinase 3 (Flt3, Fms-like tyrosine kinase-3), ...
Pharmacology and pharmacy
- 2018 •
- JSC •
- Link
Rok uplatnění
JSC - Článek v periodiku v databázi SCOPUS
Výsledek na webu
Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML
the tyrosine kinase domain and affect AML prognosis in various ways. Furthermore, FLT3-generation tyrosine kinase inhibitors, highlighting the challenges of resistance, including internal tandem duplications (FLT3...
Hematology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
New Gestational Phase-Specific Cutoff Values for the Use of the Soluble fms-Like Tyrosine Kinase-1/Placental Growth Factor Ratio as a Diagnostic Test for Preeclampsia
To establish gestational phase adapted cutoffs for the use of the soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio as a diagnostic tool for preeclampsia in the clinical setting, a mu...
FK - Gynekologie a porodnictví
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Current approach for chronic myeloid leukemia treatment with tyrosin kinase inhibitors
the discovery of a new principle of treatment in the form of inhibition of tyrosine kinases such as BCR-ABL like the main therapeutic target......
FD - Onkologie a hematologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Targeting oncogenic signaling in mutant FLT3 acute myeloid leukemia by FLT3 tyrosine kinase inhibitors
McDonough strain of feline sarcoma virus-related tyrosine kinase 3 receptor mutations are present in about 30-35 pcts of AML patients. FLT3 is a class III family transmembrane tyrosine kinase receptor whic...
Hematology
- 2020 •
- C •
- Link
Rok uplatnění
C - Kapitola v odborné knize
Výsledek na webu
13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the ...
Oncology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells
Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy-chelating agents, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) or di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazo...
Pharmacology and pharmacy
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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