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Biophysical studies on the stability of DNA intrastrand cross-links of transplatin
intrastrand crosslinks, but their stability depends on the sequence context. In some sequences the 1,3-GNG intrastrand crosslinks formed by transplatin in double-helical DNA readily rearrange into interstrand ...
BO - Biofyzika
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex
An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-di-aminocyclohexane)2+ (th...
BO - Biofyzika
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Recognition of major DNA adducts of enantiomeric cisplatin analogs by HMG box proteins and nucleotide excision repair of these adducts.
We examined HMG domain protein recognition of major 1,2-GG intrastrand DNA crosslinks, formed by two bifunctional enantionneric analogs of antitumor cis-diamminedichloroplatinum(II) (cisplatin), and removal of these crosslinks
BO - Biofyzika
- 2002 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent.
The paper contains the results describing a kink and unwinding of the DNA double-helix induced by the formation of the 1,2-GG intrastrand crosslink of antitumor cis-diamminedichloroplatinum(II) (cisplatin) in the dependence on the n...
BO - Biofyzika
- 2002 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media
DNA modifications by new dinuclear RuII arene compounds were studied. The complexes bind DNA forming intrastrand and interstrand cross-links in one DNA molecule. An intriguing aspect of the DNA-binding mode of these dinuclear RuII compounds ...
BO - Biofyzika
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Mechanism of the formation of DNA-protein cross-links by antitumor cisplatin
The ternary DNA-cisplatin-protein cross-links are formed by the transformation of DNA monofunctional and intrastrand cross-links of this metallodrug. The bulky DNA-protein cross-links formed by cisplatin represent a more distinct and persist...
BO - Biofyzika
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Cisplatin GG-crosslinks within single-stranded DNA: Origin of the preference for left-handed helicity
Molecular dynamics (MD) simulations of the single-stranded DNA trinucleotide TG*G*, with the G* guanines crosslinked by the antitumor drug cisplatin, were cisplatin-DNA adducts, the crosslinked guanines adopt a left-handed helical o...
CD - Makromolekulární chemie
- 2012 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex
forms a 1,2-d(GpG) intrastrand adduct, the equivalent of the major DNA lesion. The energetic consequences of the intrastrand cross-link at the d(GG) site are discussed......
BO - Biofyzika
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Raman spectroscopy of DNA modified by intrastrand cross-links of antitumor cisplatin
Raman spectroscopy was employed to characterize the perturbations to DNA conformation induced in DNA by two different intrastrand adducts of antitumor cis-diamminedichloroplatinum(II) (cisplatin), namely by its 1,2-GG or 1,3-GTG intrastr...
BO - Biofyzika
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Conformation of DNA intrastrand and interstrand cross-links of novel antitumor trinuclear platinum complex BBR3464.
Analysis of conformation of DNA intrastrand and interstrand cross-links of novel antitumor trinuclear platinum complex BBR3464...
BO - Biofyzika
- 2001 •
- D
Rok uplatnění
D - Stať ve sborníku
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