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18 184 (0,136s) •

Result

Distinct functions of human RecQ helicases during DNA replication

DNA replication is the most vulnerable process of DNA metabolism in the genome maintenance during DNA replication is underlined by association of defects involved in the maintenance of replication...

Biochemistry and molecular biology

  • 2017
    • •
  • Jimp
    • •
  • Link
Result

The microarchitecture of DNA replication domains

Most DNA synthesis in HeLa cell nucleus is concentrated in discrete foci. Two types of DNA synthetic sites/replication factories can be distinguished at ultrastructural level: (1) electron-dense structures--replication<...

EB - Genetika a molekulární biologie

  • 2006
    • •
  • Jx
Result

Dynamics of DNA replication: an ultrastructural study

We have characterized the dynamics of DNA synthesis in synchronized mid-S-phase HeLa cells. These results demonstrate that DNA replication is compartmentalized within cell nuclei at the level of DNA foci and suppor...

EA - Morfologické obory a cytologie

  • 2004
    • •
  • Jx
Result

A Fraction of MCM 2 Proteins Remain Associated with Replication Foci During a Major Part of S Phase

The essential role of MCM 2-7 proteins in the initiation of DNA replication proteins are displaced after replication initiation from sites of DNA replication immunofluorescence localization of MCM 2 protei...

EA - Morfologické obory a cytologie

  • 2011
    • •
  • Jx
    • •
  • Link
Result

Role of PCNA and RFC in promoting Mus81-complex activity

Background: Proper DNA replication is essential for faithful transmission intermediates and promotes POLD3-dependent DNA synthesis via break-induced replication of replicative DNA polymerases that...

Human genetics

  • 2017
    • •
  • Jimp
    • •
  • Link
Result

The absence of a DNA replication checkpoint in porcine zygotes

It has been demonstrated that in zygotes of some mammals the unique checkpoint controls the onset of DNA replication.Thus, DNA replication begins in the maternal show that the onset of DNA replication occu...

EB - Genetika a molekulární biologie

  • 2006
    • •
  • Jx
Result

Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments

completely inhibiting DNA replication: it does not induce the generation of single not activate the replication checkpoint nor DNA damage response. Emetine is also replication of DNA. Mechanistic...

Other biological topics

  • 2022
    • •
  • Jimp
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  • Link
Result

DNA Replication: From Radioisotopes to Click Chemistry

The replication of nuclear and mitochondrial DNA are basic processes assuring principles of DNA replication, and also in the studies focused on the cell cycle that serve as markers of newly synthesized DNA...

Biochemistry and molecular biology

  • 2018
    • •
  • JSC
    • •
  • Link
Result

Ori-somes, NP complexes descending from origin regions of animal chromosomal DNA replication. A micromorphological study.

Micromorphology of nucleoprotein (NP) complexes designated according to their descent and shape as Ori-somes is presented. These NP compexes ofthree different types harbor molecules of cytoplasmic 'small' polydisperse DNA, which descend from...

EB - Genetika a molekulární biologie

  • 2001
    • •
  • Jx
Result

Perspectives on PARPs in S Phase

Accurate copying of DNA during S phase is essential for genome stability and cell viability. During genome duplication, the progression of the DNA replication have evolved several mechanisms that protect DNA re...

Cell biology

  • 2019
    • •
  • Jimp
    • •
  • Link
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