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15 541 (0,198s) •

Result

DNA photocleavage by DNA and DNA-LNA amino acid-dye conjugates

This work describes the synthesis of conjugates of the triplex forming oligonucleotides (TFOs) and their photoreactivity toward the mdm2 gene in its DNA plasmid form and in a synthetic DNA duplex containing the TFO binding site....

BO - Biofyzika

  • 2010
    • •
  • Jx
Result

Enhanced DNA Photocleavage and Binding properties of sapphyrin-Polyamine Conjugates

CB - Analytická chemie, separace

  • 1997
    • •
  • Jx
Result

Interaction of dinuclear ruthenium(II) supramolecular cylinders with DNA: sequence-specific binding, unwinding, and photocleavage

We explored DNA unwinding and sequence-specific binding properties, as well as DNA photonuclease activity of ruthenium(II) metallosupramolecular cylinder [Ru2L3]4+. We found that [Ru2L3]4+ unwinds negatively supercoiled plasmid ...

AQ - Bezpečnost a ochrana zdraví, člověk – stroj

  • 2008
    • •
  • Jx
Result

NMR analysis of duplex d(CGCGATCGCG)2 modified by lambda- and delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study

by means of 1H NMR spectroscopy. In addition, photocleavage studies were also conducted cleave DNA with similar efficiency, attacking mainly the guanines of the sequence......

BO - Biofyzika

  • 2007
    • •
  • Jx
Result

Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex

)) to the DNA photocleavage process cannot be entirely excluded. Notably, the mechanism of DNA photocleavage by 1 appears to involve a direct modification of mainly thoseWe report DNA cleavage by ruthenium...

BO - Biofyzika

  • 2016
    • •
  • Jx
    • •
  • Link
Result

DNA binding selectivity of oligopyridine-ruthenium(II)-lysine conjugate

The synthesis, characterization and DNA binding properties of the complex [Ru(terpy)(4,4'-(COLysCONH2)2bpy)Cl]3+ have been studied by UV-Vis, CD and LD spectroscopy, NMR spectroscopy and gel electrophoresis....

BO - Biofyzika

  • 2011
    • •
  • Jx
Result

Oligopyridine-ruthenium(II)-amino acid conjugates: synthesis, characterization, DNA binding properties and interactions with the oligonucleotide duplex d(5'-CGCGCG-3')2

Diastereomeric oligopyridine-ruthenium(II)-amino acid conjugated complexes of the general formulas lambda- and delta-[Ru(bpy)2(4,4'(CO2Y)2-bpy)]2+, where Y = L-AlaCONH2, L-LysCONH2, L-HisCONH2, L-TyrCONH2, were synthesized and characterized. Their bi...

BO - Biofyzika

  • 2009
    • •
  • Jx
Result

Orthogonal Photocleavage of a Monochromophoric Linker

The 4-acetyl-2-nitrobenzyl moiety, substituted in both benzylic and phenacyl positions with leaving groups, has been proposed as a monochromophoric photocleavable linker. The attached groups can be disconnected selectively and orthogonally upon irrad...

CC - Organická chemie

  • 2010
    • •
  • Jx
Result

Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

properties so that DNA photocleavage and synergistic enhancement of DNA damage due mechanisms of action involving interactions with DNA, but distinctly different from those of the approved platinum anticancer drug...

Inorganic and nuclear chemistry

  • 2018
    • •
  • Jimp
    • •
  • Link
Result

Green-light photocleavable meso-methyl BODIPY building blocks for macromolecular chemistry

the ability of these compounds to undergo photocleavage in green light (lambda > 500 nm by incorporating the diols into polyurethane hydrogels shown to undergo photocleavage and hence......

Polymer science

  • 2021
    • •
  • Jimp
    • •
  • Link
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