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Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm
that Pax6 directly controls expression of several Wnt inhibitors such as Sfrp1, Sfrp2 development. Thus Pax6 is required for down-regulation of canonical Wnt signaling in the surface-ectoderm. Supression of canoni...
EB - Genetika a molekulární biologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Genetic interaction between Pax6 and ?-catenin in the developing retinal pigment epithelium
between Pax6and Wnt/beta-catenin signaling pathway by analyzing Pax6, beta-catenin, and Pax6/beta-catenin conditional knockout mice. Although Pax6 inactivation alone hadWnt/beta-catenin signaling plays an...
EB - Genetika a molekulární biologie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus
retreat of canonical Wnt signaling in the cortex from lateral-to-medial and anterior fusion protein maintains active canonical Wnt signaling in developing cortex and delays expression onset of neurogenic factors Pax6, Ngn2...
EB - Genetika a molekulární biologie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Tcf7L2 is essential for neurogenesis in the developing mouse neocortex
, the Wnt activity is reduced, ventricular zone markers Pax6 and Sox2 are downregulated of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling expression of two transcrtiption factors me...
Biochemistry and molecular biology
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Ectopic Activation of Wnt/beta-Catenin Signaling in Lens Fiber Cells Results in Cataract Formation and Aberrant Fiber Cell Differentiation
The Wnt/beta-catenin signaling pathway controls many processes during investigated the effect of ectopic activation of Wnt/beta-catenin signaling during lens fiber cell differentiation. To activate Wnt/beta-catenin signalin...
FF - ORL, oftalmologie, stomatologie
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of .alfa.5.beta.1 integrin expression.
The PAX6 gene, a key regulator of eye development, produces two major proteins that differ in paired domain structure: PAX6 and PAX6(5a). It is known that an increase in the PAX6(5a) to PAX6 ratio leads to...
EB - Genetika a molekulární biologie
- 2000 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The Optimedin gene is a downstream target of Pax6
pattern of the Optimedin A variant in the eye and brain overlaps with that for Pax6. The Pax6 gene plays a critical role for the development of eyes, central nervous system Pax6 binding site in position ?86/?70. Pax6
EB - Genetika a molekulární biologie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Complex regulatory element within the E- and F-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid.
A new regulatory element recognized by Pax6 and the alernatively spliced Pax6(5a) isoform was identified within an enhancer region of E- and F-crystallin genes. Mutation of the Pax6 binding site, which is adjacent to a reti...
EB - Genetika a molekulární biologie
- 2002 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Ancestral role of Pax6 in chordate brain regionalization
The Pax6 gene is essential for eye and brain development across various animal species. Here, we investigate the function of Pax6 in the development of the anterior-induced genome editing. Specifically, we examined Pax6 mut...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Multiple roles of Pax6 in postnatal cornea development
to conditionally deplete Pax6 proteins in two domains of ocular cells, i.e., the ocular surface-cre, respectively. Earlier and broader inactivation of Pax6 in the OSE resulted pattern. More restricted depletion of Pax6 in ...
Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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