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Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir
While adefovir does not influence viability of macrophages and splenocytes, adefovir dipivoxil possesses pronounced cytocidal activity. The toxicity is obviously due to formaldehyde, a decomposition product of the pivoxil moiety of ...
EB - Genetika a molekulární biologie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The influence of acyclic nukleosidephosphates (adefovir and adefovir dipivoxil) at the caspase 1 activity
The influence of acyclic nukleosidephosphates (adefovir and adefovir dipivoxil) at the caspase 1 activity was studied.
FR - Farmakologie a lékárnická chemie
- 2003 •
- D
Rok uplatnění
D - Stať ve sborníku
The study of inhibitory activities of adefovir and adefovir dipivoxil on ICE convertase (caspase 1) activity
The inhivitory activity of antivirotic drugs adefovir and adefovir dipivoxyl on the activity of ICE convertase (caspase 1), important in apoptosis, was studied....
FR - Farmakologie a lékárnická chemie
- 2002 •
- D
Rok uplatnění
D - Stať ve sborníku
HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA)
Novel HPLC method for determination of adefovir was developed and validated...
FR - Farmakologie a lékárnická chemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Transdermal and dermal delivery of adefovir: Effects of pH and permeation enhancers
Transport of 2% adefovir (9-(2-phosphonomethoxyethyl)adenine) through and into porcine skin and effects of various solvents, pH, and permeation enhancers were studied in vitro using Franz diffusion cell. This study suggests that adefovir...
CC - Organická chemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir
Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat steatohepatitis on the pharmacokinetics of adefovir in rats given a control or methionine a bolus dose of 7mg/kg (35uCi/kg) [(3)H] adefovir with ...
FR - Farmakologie a lékárnická chemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Permeation enhancer dedocyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: Influence of pH, ion-pairing and skin species
Adefovir (9-(2-phosphonomethoxyethyl)adenine) is an acyclic nucleoside phosphonate currently used for the treatment of hepatitis B. The aim of this study was to evaluate the effect of permeation enhancer DDAK (6-dimethylaminohaxanoic acid do...
CC - Organická chemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes
Repeated intreaperitoneal administration of higher doses of adefovir to rats results in partial degradation of the CYP protein to inactive P420....
FR - Farmakologie a lékárnická chemie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Adefovir (PMEA) and tenofovir (PMPA) and their prodrugs, adenofir dipivoxil ( bisPOM-PMEA) and tenofovir disoproxil ( bisPOC-PMPA), were subjected to a detailed study of their potential to inhibit the activities of human liver microsomal cyt...
FR - Farmakologie a lékárnická chemie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Original scientific paper dealing with Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
FR - Farmakologie a lékárnická chemie
- 1999 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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