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MCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis
identifies mTORC1 to be modulated by MCL1 but not by the anti-apoptotic Bcl-2 or Bcl-xL. mTORC1 is a central metabolic regulator. MCL1 impacts metabolism via modulating the expression of hexokinase 2 (HK2) in an mTORC1-dep...
Polymer science
- 2025 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Integrated actions of mTOR complexes 1 and 2 for growth and development of Dictyostelium
Multi-protein complexes mTORC1 and mTORC2 are required for growth and development of eukaryotes. mTORC1 is a nutrient sensor that integrates metabolic signals, mTORC1 or mTORC2. Many protein associations and regulatory path...
Cell biology
- 2019 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway
The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell. Amino acids signal to mTORC1 by modulating the guanine nucleotide loading states of the heterodimeric Rag GTPases, which bind and recruit mTORC1...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation
Activation of the mechanistic target of rapamycin complex 1 (mTORC1) requires of mTORC1 signalling. Recently, Chen et al. suggested that KLHL22-dependent ubiquitylation and proteasomal degradation of the GATOR1 component DEPDC5 medi...
Biochemistry and molecular biology
- 2025 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway
levels and suppressed mTORC1/CREB pathway, preventing mPCa development. Metformin mTORC1 in liver and requires LKB1 to mediate glucose homeostasis. We find reduced tumor growth accompanied by diminished mTORC1/CREB, AR and...
Biochemistry and molecular biology
- 2023 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signaling in melanoma cells
mTORC1 and mTORC2 driven by different feedback loops, decreases the therapeutic that the mTORC1 signalling pathway is highly activated in human melanoma cells and that up kinase activity, decreased up-regulation of the mTORC1
FD - Onkologie a hematologie
- 2013 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Inhibition of mTORC1 by SU6656, the Selective Src Kinase Inhibitor, Is Not Accompanied by Activation of Akt/PKB Signalling in Melanoma Cells
mTORC1 and mTORC2 driven by different feedback loops, decreases the therapeutic that the mTORC1 signalling pathway is highly activated in human melanoma cells and that up kinase activity, decreased up-regulation of the mTORC1
CE - Biochemie
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling
belonged to the components of the PI3/AKT/mTORC1/autophagy pathway. To assess in mice and zebrafish. These experiments revealed that mTORC1 signaling modulates fine-tuning during clonal intercalation. This ability of mTORC1
Other natural sciences
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway
Animals sense and respond to nutrient availability in their environments, a task coordinated in part by the mTOR complex 1 (mTORC1) pathway. mTORC1 regulates in different metazoan phyla. Whether such customization occurs, and how th...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Structural basis for the dynamic regulation of mTORC1 by amino acids
The mechanistic target of rapamycin complex 1 (mTORC1) anchors a conserved. Amino acids activate mTORC1 through the Rag GTPases, which are regulated by GATOR the ability of mTORC1 to sense individual amino acids. We also re...
Biochemistry and molecular biology
- 2025 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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