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Substrate Specificity, Inhibition and Enzymological Analysis of Recombinant Human Glutamate Carboxypeptidase II.
Study of activity and inhibition of recombinant Glutamate Carboxypeptidase II.
FH - Neurologie, neurochirurgie, neurovědy
- 2002 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Biochemical characterization of human glutamate carboxypeptidase III
The work describes characterization of glutamate carboxypeptidase III, the human homolog of glutamate carboxypeptidase II. A number of inhibitors were tested, enzyme substrate specifity was verified and a ...
CE - Biochemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II
Refining the structure of glutamate carboxypeptidase II to the resolution of 1.65 angstrom.
CE - Biochemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Glutamate Carboxypeptidase II as a Therapeutic Target
Review summarizing structural, biological and enzymological information on glutamate carboxypeptidase II and its human and animal homologs....
CE - Biochemie
- 2012 •
- C •
- Link
Rok uplatnění
C - Kapitola v odborné knize
Výsledek na webu
Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding
The artcle describes that amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding......
CE - Biochemie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Structural insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II
Crystal structure of glutamate carboxypeptidase II complexed with three glutamate mimetics.
CE - Biochemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
Crystal structure of extracellular part of GCPII with inhibitors...
CE - Biochemie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Biochemical characterisation of human glutamate carboxypeptidase III
Cloning, expression and characterization of glutamate carboxypeptidase III.
CE - Biochemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Detection and quantitation of glutamate carboxypeptidase II in human blood
BACKGROUND Glutamate carboxypeptidase II (GCPII) is a transmembrane enzyme that cleaves N-acetyl-L-aspartyl-L-glutamate (NAAG) in the brain. GCPII is highly expressed in the prostate and prostate cancer and might b...
CE - Biochemie
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II
We present here a structure-aided design of inhibitors targeting the active site as well as exosites of glutamate carboxypeptidase II (GCPII), a prostate more active toward, GCPII than its closest human homologue, gluta...
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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