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Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt-II complexes
DNA adducts of bifunctional antitumor cisplatin or monodentate [PtCl(dien)]Cl (dien = diethylenetriamine) inhibit eukaryotic topoisomerase 1 (top1) action, the adducts of cisplatin being more effective. Th...
BO - Biofyzika
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
ELISA-like Analysis of Cisplatinated DNA Using Magnetic Separation
Cisplatin belongs to the most widely used cytostatic drugs. The determination of the presence of the DNA-cisplatin adducts may not only signal the guanine-rich regions on specific recognition of DNA-ci...
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer
characterized the effects of DNA adducts of cisplatin and ineffective transplatin for cisplatin. The distinctive structural features of DNA adducts of the two platinum site-NF-B protein interacti...
BO - Biofyzika
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Different recognition of DNA modified by antitumor cisplatin and its clinically ineffective trans isomer by tumor suppressor protein p53
that DNA adducts of cisplatin reduced binding affinity of the consensus DNA sequence conformational perturbances induced in DNA by cisplatin adducts. The resultsalso demonstrateDNA
BO - Biofyzika
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.
shown that this adduct inhibits DNA synthesis and creates a local conformational of the monofunctional DNA adducts of the trans-platinum analogues in tumor cells may be similar to that of the major bifunctional
BO - Biofyzika
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin
The results indicate that structurally different DNA adducts of antitumor trinuclear platinum compound BBR3464 and cisplatin exhibit a different efficiency to affect the binding affinity of the modified DNA to p53 ...
BO - Biofyzika
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner
DNA modification with the antitumor drug cisplatin inhibits the p53 binding to a synthetic p53CON. Effects of DNA modification with cisplatin on binding of the p53 binding towards the cisplatin DNA
BO - Biofyzika
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins
as it does tothe adduct of antitumor cisplatin, and to the adduct formed by the S to the ahaz adducts than to the cisplatin adducts formed at the TGGT sequenceThe bending, unwinding, and structur...
BO - Biofyzika
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA Adducts of cisplatin, transplatin and platinum-intercalating drugs.
Annotation not available...
BO - Biofyzika
- 1994 •
- D
Rok uplatnění
D - Stať ve sborníku
Superhelical torsion controls formation of DNA adducts of antitumor cisplatin.
Annotation not available...
BO - Biofyzika
- 1996 •
- D
Rok uplatnění
D - Stať ve sborníku
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