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26 (0,077s)

Result

Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)-methoxy]-2-hydroxypropyl}adenine and its free phosphonates substituted at the C-8 position of purine base

New approach to 9-[2-hydroxy-3-(phosphonomethoxy)propyl]adenine (iso-HPMPA) is described and a series of iso-HPMPA derivatives substituted at the C-8 position of the purine ring was prepared. Synthesis of the key alkylating agent wa...

CC - Organická chemie

  • 2010
  • Jx
Result

Metal Ion-Coordinating Properties in Aqueous Solutions of the Antivirally Active Nucleotide Analogue (S)-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) - Quantification of Complex Isomeric

]adenine (HPMPA) and include for comparison 9‐[2‐(phosphonomethoxy)ethyl]adenine (PMEA‐(phosphonomethoxy)propane (HPMP). The acidity constants of H3(HPMPA)+ were determined, the stability constants of the M(H,HPMPA)+ and M(...

Organic chemistry

  • 2019
  • Jimp
  • Link
Result

An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives.

Annotation not available...

CC - Organická chemie

  • 1999
  • D
Result

Tetrahydrofurane Ring-Containing Nucleotide Analogs Related to HPMPA and PMEA.

Annotation not available...

CC - Organická chemie

  • 1996
  • D
Result

Metal Ion-Coordinating Properties of Antiviral Adenine (HPMPA) and Cytosine (HPMPC) Phosphonate-Derivatives.

Annotation not available...

CC - Organická chemie

  • 1995
  • Jx
Result

Acid-base properties of an antivirally active acyclic nucleoside phosphonate: (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA)

HPMPA is an acyclic nucleoside phosphonate analogue of AMP which displays., binding to enzymes, coordination of metal ions) of general interest. HPMPA can accept measured the chemical shifts of the nine non-exchangeable HPMPA

Organic chemistry

  • 2022
  • Jimp
  • Link
Result

Metal Ion Complexes of the Antiviral ( S )-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) in Solution.

Annotation not available...

CC - Organická chemie

  • 1995
  • Jx
Result

[5-(9-Adeninyl)-5'-deoxy-L-pentofuranosyl]phosphonates: Conformationally Restricted Nucleotide Analogs Related to ( S )-HPMPA.

Annotation not available...

CC - Organická chemie

  • 1993
  • Jx
Result

( S )-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [( S )-HPMPA]: a Purine Analogue with Trypanocidal Activity in vitro and in vitro .

Annotation not available...

CC - Organická chemie

  • 1996
  • Jx
Result

Nucleotide analogues with immunobiological properties: 9-[2-hydroxy-3-(phosphonomethoxy)propyl]adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives

Acyclic nucleoside phosphonate 9-[2-hydroxy-3-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) augments production of nitric oxide by macrophages and stimulates secretion of cytokines and chemokines implied in replication and/or penetration of H...

EB - Genetika a molekulární biologie

  • 2006
  • Jx
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