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27 962 (0,113s)

Result

Konstantin Biebl and his Nový Ikaros

Study dwells on poem Nový Ikaros from Konstantin Biebl.

AJ - Písemnictví, mas–media, audiovize

  • 2005
  • Jx
Result

Treatment of lymphoid and myeloid malignancies by immunomodulatory drugs

Thalidomide and its derivatives (lenalidomide, pomalidomide, avadomide, iberdomide hydrochoride, (CC-885 and CC-90009) form the family of immunomodulatory drugs (IMiDs). Cereblon acts as the substrate receptor of a cullin-4 really interestin...

Hematology

  • 2019
  • JSC
  • Link
Result

Exotism and Apollinaire's influence in Biebl's S lodí jež dováží čaj a kávu and Nový Ikaros

The study deals with the work of the Czech poet Konstantin Biebl that was inspired by his journey to Java island (S lodí jež dováží čaj a kávu, Nový Ikaros). It also focuses on exploring the influence of the French poet Guillaume Apollinaire...

AJ - Písemnictví, mas–media, audiovize

  • 2011
  • Jx
Result

Cereblon as the cellular target responsible for the anti-multiple myeloma activity of immunomodulatory drugs (thalidomide, lenalidomide and pomalidomide)

. Two target proteins, the zinc finger-containing transcription factors Ikaros...

FD - Onkologie a hematologie

  • 2014
  • C
Result

Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia

IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia. Recent studies suggest that IKZF1 is also involved in myeloid differentiatio...

FD - Onkologie a hematologie

  • 2015
  • Jx
  • Link
Result

Ikaros (IKZF1) alterations and minimal residual disease at day 15 assessed by flow cytometry predict prognosis of childhood BCR/ABL-negative acute lymphoblastic leukemia

Background Recently, several studies have demonstrated a negative prognostic impact of Ikaros (IKZF1) gene alterations in acute lymphoblastic leukemia (ALL). However, controversies still exist regarding the impact of IKZF1 in current treatme...

FD - Onkologie a hematologie

  • 2013
  • Jx
  • Link
Result

Comments

Comments on the critical edition Konstantin Biebl's powtical works (Věrný hlas, Zlom, Zloděj z Bagdadu, Zlatými řetězy, S lodí jež dováží čaj a kávu, Nový Ikaros, Nebe peklo ráj, Zrcadlo noci)....

AJ - Písemnictví, mas–media, audiovize

  • 2014
  • C
Result

Iberdomide: cereblon E3 ligase modulator (CELMoD): treatment of systemic lupus erythematosus: treatment of multiple myeloma

Iberdomide (CC-220) is a cereblon (CRBN)-binding drug with antitumor and immunostimulatory activities.

Hematology

  • 2021
  • Jimp
  • Link
Result

Advancements in the treatment of adult acute lymphoblastic leukaemia

genetic abnormalities, such as IKZF1 (Ikaros) and NOTCH1 gene mutations and on the new...

FD - Onkologie a hematologie

  • 2015
  • Jx
Result

Rationale of targeting protein cereblon as a potential strategy for cancer treatment

Thalidomide and its related agents (lenalidomide, pomalidomide, avadomide, iberdomide hydrochloride, CC-885, CC- 90009 and CC-92480) form the family of immunomodulatory or cereblon (CRBN) binding drugs (IMiDs) with anticancer and anti-inflam...

Hematology

  • 2020
  • Jimp
  • Link
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