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Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
is M17 leucyl-aminopeptidase (LAP). Here, we aimed to chemically validate LAP. Thermal proteome profiling revealed that these inhibitors thermally stabilized two M17......
Cell biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
are urgently required. Here we identified inhibitors of the acidic M17 leucyl-aminopeptidase from T. cruzi (LAPTc) that show promise as novel starting points for Chagas......
Infectious Diseases
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Isozymes of phosphatase and leucine and leucine aminopeptidase as biochemical markers for purity testing in rapeseed androgenetic lines.m
EB - Genetika a molekulární biologie
- 1994 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
is M17 leucyl-aminopeptidase (LAP). Here, we aimed to chemically validate LAP. Thermal proteome profiling revealed that these inhibitors thermally stabilized two M17......
Cell biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei
the daughter kDNA networks prior to their segregation. Here we characterize an M17 family leucyl aminopeptidase metalloprotease, termed TbLAP1, which specifically localizes......
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei
the daughter kDNA networks prior to their segregation. Here we characterize an M17 family leucyl aminopeptidase metalloprotease, termed TbLAP1, which specifically localizes......
Genetics and heredity (medical genetics to be 3)
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry
Leucyl aminopeptidases (LAPs) are involved in multiple cellular functions, which, in the case of infectious diseases, includes participation in the pathogen-host cell interface and pathogenesis. Thus, LAPs are considered good candidate drug ...
Biological sciences
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine
Ligands containing bulky aliphatic P1 residues exhibit a high affinity towards cytosolic leucine aminopeptidase, a bizinc protease of biomedical significance. According to this specificity, a series of phosphonic and phosphinic comp...
CC - Organická chemie
- 2011 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Acid phosphatase and leucine aminopeptidase isozymes as biochemical markers of homogenity in oil seed rape androgenetic lines
EB - Genetika a molekulární biologie
- 1994 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Acid phosphatase and leucine aminopeptidase isozymes as biochemical markers of homogenity in oil seed rape androgenetic linies
EB - Genetika a molekulární biologie
- 1995 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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