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Plasmafiltration as a possible contributor to kinetic targeting of pegylated liposomal doxorubicin (PLD) in order to prevent organ toxicity and immunosuppression

To examine the removal of pegylated liposomal doxorubicin during plasmafiltration and determine whether the drug could be withheld prior to its organ distribution responsible for mucocutaneous toxicity. Six patients suffering from platinum-r...

FJ - Chirurgie včetně transplantologie

  • 2016
    • •
  • Jx
    • •
  • Link
Result

Plasmafiltration as an effective method in the removal of circulating pegylated liposomal doxorubicin (PLD) and the reduction of mucocutaneous toxicity during the treatment of advanced platinum

The present study evaluates the safety and efficacy of double-plasma filtration (PF) to remove the exceeding pegylated lipposomal doxorubicin (PLD) in ciculation, thus reducing mucocutaneous toxicity. PF can be considered as safe and effective for th...

Oncology

  • 2020
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  • Jimp
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  • Link
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