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HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity
Synthesis, physicochemical and biological properties and preliminary anticancer activity of new star-shaped polymer?doxorubicin (DOX) conjugates targeted with anti-CD20 monoclonal antibody were investigated. New method of synthesis ...
CD - Makromolekulární chemie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Enzymatically degradable polyurethanes based on poly(ethylene glycol) conjugated with doxorubicin and antibodies in cancer therapy.
Synthesis and anti-tumor activity of two types of polymer-drug conjugates with an antibody is described. The conjugates contain an anti-cancer drug, doxorubicin and antibodies in cancer therapy....
EC - Imunologie
- 2003 •
- D
Rok uplatnění
D - Stať ve sborníku
Clinical and pharmacological aspects of biological and targeted therapies
of antibodies, e.g. body weight (obesity), anti-drug antibody formation, drug interactions or some pathological states and examples focused mainly on anti-IgE, anti-IL5 or anti ...
Pharmacology and pharmacy
- 2019 •
- Jost •
- Link
Rok uplatnění
Jost - Ostatní články v recenzovaných periodicích
Výsledek na webu
Therapeutic Monoclonal Antibodies in Treatment and Development
to the formation of anti-drug antibodies in the patient organism are also mentioned.This review is devoted to the therapeutic use of monoclonal antibodies, which are probably the most important group of biological...
FR - Farmakologie a lékárnická chemie
- 2013 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab')2-targeted conjugates and combined therapy with immunomodulators.
Original scientific paper dealing with Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab')2-targeted conjugates and combined therapy with immunomodulat...
EC - Imunologie
- 2000 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real
Antibodies against biologic drugs decrease drug concentrations and thus influence clinical results. Aim of the study was to prove, how antibodies against adalimumab, etanercept and infliximab influence results of t...
Rheumatology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Monoclonal Antibodies and Antibody Drug Conjugates in Multiple Myeloma
in multiple myeloma during the last decade. The use of antibodies as well as antibody drug the last years. More specifically, monoclonal anti-CD38 antibodies, daratumumab to refractory disease. In additio...
Oncology
- 2021 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Conjugates of antibody-targeted PEG multiblock polymers with doxorubicin in cancer therapy.
by aminolysis of polymer-Dox sulfosuccinimidyl ester with antibody. Both the polymers, with and without the antibody, exhibited a significantly higher anti-cancer activity againstEL4 lymphoma in vivo than free Dox though a...
CD - Makromolekulární chemie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Immunogenicity of biologic therapies and monitoring of their pharmacokinetics in clinical practice
of the drug in serum. Development of anti-drug antibodies may be responsible for low drugBiologic therapy with anti-TNFα agents represents a very effective treatment modality in inflammatory bowe...
Pharmacology and pharmacy
- 2017 •
- Jost
Rok uplatnění
Jost - Ostatní články v recenzovaných periodicích
ELISA-like Analysis of Cisplatinated DNA Using Magnetic Separation
of a complex between magnetic particles with surface modified by anti-dsDNA antibody, cisplatin-modified DNA and QDs labelled anti-cisplatin-modified DNA antibodyCisplatin belongs to the most widely used cytostati...
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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