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28 163 (0,097s) •

Result

The importance of diazepam and oxime HI-6 for antidotal treatment of acute poisoning with VX compound in mice

The effect of basic antidotal treatment and diazepam in acute poisoning with organophosphorus compounds was investigated in experiments on mice of the NMRI strain. While supplementing the basic antidotal treatment with diazepam does not incr...

FP - Ostatní lékařské obory

  • 2002
    • •
  • Jx
Result

Asymmetric biocatalysis of the nerve agent VX by human serum paraoxonase 1: Molecular Docking and Reaction Mechanism calculations

paraoxonase 1 (wild-type and mutants) enzymes and the VX compound, one of the most toxicOrganophosphorus compounds have been employed in agricultural activity, these compounds have also been used as chemical weapo...

Organic chemistry

  • 2016
    • •
  • Jimp
    • •
  • Link
Result

Chemistry of Sarin and similar compounds

Nerve paralytic agents of general structure MeP(O)(OR)F (Sarin, Soman, Cyklosin) as well as agents of the VX and Vx type MeP(O)(SCH2CH2NR2)OR are described and their properties are discussed from the stand point of view of their tox...

AM - Pedagogika a školství

  • 2014
    • •
  • Jx
Result

Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX

disease. This compound has also been successfully tested for pretreatment agents (VX and Russian VX). According to the obtained results, Hup A was able by Russian VX and VX....

FP - Ostatní lékařské obory

  • 2009
    • •
  • Jx
Result

New Group of Supertoxic Organophosphorus Compounds

warfares agents (CWA), sarin GB and VX agent (GB-2 and VX-2 respectively) and thus and relatively low effectiveness of VX over any clothing barrier given with its extremely......

CC - Organická chemie

  • 2012
    • •
  • Jx
Result

Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX

potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising com...

FP - Ostatní lékařské obory

  • 2006
    • •
  • Jx
Result

Structure-Activity Relationship for the Reactivators of Acetylcholinesterase Inhibited by Nerve Agent VX

Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with t...

FR - Farmakologie a lékárnická chemie

  • 2013
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  • Jx
    • •
  • Link
Result

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

compound resulted as better reactivator of NEMP (VX surrogate)-inhibited BChE than was designed and prepared for cholinesterase reactivation purposes. The novel compounds (BChE) inhibition, when the majority of novel c...

Pharmacology and pharmacy

  • 2020
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  • Jimp
    • •
  • Link
Result

In vitro searching for a new potent reactivator of acetylcholinesterase inhibited by nerve agent VX

Organophosphorus compounds, especially nerve agents, inhibit enzyme acetylcholinesterase (AChE; EC 3.1.1.7) in an irreversible manner. Atropine plus an oxime chemical structures in reactivation of VX-inhibited AChE. Rat brain AChE h...

FP - Ostatní lékařské obory

  • 2005
    • •
  • Jx
Result

Russian VX: Inhibition and reactivation of acetylcholinesterase and its comparison with VX-agent

Organophosphorus compounds such as nerve agents inhibit, practically irreversible, cholinesterases (ChEs) by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent (NA inh...

FP - Ostatní lékařské obory

  • 2006
    • •
  • Jx
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