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Pronounced cellular uptake of pirarubicin versus that of other anthracyclines: comparison of HPMA copolymer conjugates of pirarubicin and doxorubicin
drugs appear more important than the same carrier polymer in this case. Pirarubicin (THP), a tetrahydropyranyl derivative of doxorubicin (DOX), demonstrated more rapid cellular internalization and potent cytotoxicity than DOX. Here...
CD - Makromolekulární chemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice
) conjugates of pirarubicin (THP), LP-THP, with MW about 39 kDa, exhibited far better tumor accumulation and therapeutic effect than that of parental free THP. To improve the pharmacokinetics of LP-THP fur...
CD - Makromolekulární chemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage
) conjugated with pirarubicin (THP) via a hydrazone bond (PHPMA-hyd-THP) is a drug conjugate that releases THP in the acidic milieu of a tumor. PHPMA-hyd-THP has protein binding. PHPMA-hyd-THP pos...
CD - Makromolekulární chemie
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Superior penetration and cytotoxicity of HPMA copolymer conjugates of pirarubicin in tumor cell spheroid
N-(2-Hydroxypropyl)methacrylamide copolymer conjugates of pirarubicin (THP), P-THP, accumulates selectively in solid tumor tissue by the enhanced permeability that cellular uptake of P-THP was 25 times less than th...
Polymer science
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Missile-type tumor-targeting polymer drug, P-THP, seeks tumors via three different steps based on the EPR effect
-hydroxypropyl) methacrylamide (HPMA) copolymer-conjugated pirarubicin (P-THP), which uses ensured selective and rapid release of the active drug, pirarubicin (THP), in acidic, doxorubicin), THP demonstrat...
CD - Makromolekulární chemie
- 2016 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Structure-to-efficacy relationship of HPMA-based nanomedicines: the tumor spheroid penetration study
-based nanomedicines carrying anticancer drug pirarubicin (THP) on the penetration and star-like copolymers and also their conjugates with THP was observed, THP penetration after nanomedicines application was consi...
Polymer science
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study
containing pirarubicin (THP) conjugated to N-(2-hydroxypropyl) methacrylamide copolymer (PHPMA), [P-THP], through a spacer containing pH-sensitive hydrazone bond pilot study. Toward clinical development, here we report
Pharmacology and pharmacy
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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HPMA copolymer-conjugated pirarubicin in multimodal treatment of a patient with stage IV prostate cancer and extensive lung and bone metastases
the first clinical application of a new agent?HPMA copolymer-conjugated pirarubicin (P-THP)?with a molecular size of about 8 nm, or 38.5 kDa. A patient had advanced prostate cancer, and P-THP was administered for numerous ...
CD - Makromolekulární chemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Augmentation of the enhanced permeability and retention effect with nitric oxide-generating agents improves the therapeutic effects of nanomedicines
, often seen in clinical settings, 2 mg/kg polymer-conjugated pirarubicin (P-THP) with NG (0.2 mg/mouse) showed better effects than did 5 mg/kg P-THP, and 5 mg/kg P-THP-THP even after just one injection, r...
Polymer science
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines
to an anthracycline drug pirarubicin (THP) via a pH-sensitive hydrazone bond achieving up to 21 wt% of THP. The DHPMA copolymers were extensively compared to the well-known drug-based copolymers and did not aggregate even ...
Polymer science
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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