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18 835 (0,134s) •

Result

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases.

. The purine Cdk specific inhibitor (R)-roscovitine (seliciclib, CYC202) represents one concerning cancer therapy. Recently, we have shown that roscovitine exerts potent derivatives of roscovitine in vitro...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2011
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  • Jx
Result

Purvalanol A, Olomoucine II and Roscovitine Inhibit ABCB1 Transporter and Synergistically Potentiate Cytotoxic Effects of Daunorubicin In Vitro

, weinvestigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine: Olomoucine II most strongly, followed by roscovitine, purvalanol A, and flavopiridol. SNS in ABCB1 membrane preparations, while olomoucine II and ...

FR - Farmakologie a lékárnická chemie

  • 2013
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  • Jx
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  • Link
Result

BOHEMINE IN VITRO CYTOTOXIC ACTIVITY IN PRIMARY TUMOUR CELLS

Cyclin dependent kinases complexed with cyclins trigger eukaryotic cell cycle proliferation by phosphorylation of specific target protein. Synthetic inhibitors of cyclin dependent kinases (CDKIs) as olomoucine (OC), bohemine (BOH), R-ros...

FD - Onkologie a hematologie

  • 2006
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  • Jx
Result

High Performance Liquid Chromatography-Electrochemistry-Electrospray Ionization Mass Spectrometry (HPLC/EC/ESI-MS) for Detection and Characterization of Roscovitine Oxidation Products

-trisubstitutedpurine, R-roscovitine, which is known to be an inhibitor of some cyclin-dependent kinases (CDKs) and a potential anticancer drug. Oxidation of R-roscovitine identified R-roscovitine...

CB - Analytická chemie, separace

  • 2011
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  • Jx
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Result

Platinum(II)-oxalato complexes of seliciclib (CYC202) derivatives show different cellular effects and lesser adverse effects in mouse lymphoma model than cisplatin

This work presents a deeper pharmacological evaluation of two formerly prepared and characterized, and highly in vitro cytotoxic platinum(II) oxalato complexes [Pt(ox)(L-1)(2)] (1) and [Pt(ox)(L-2)(2)] (2), containing the derivatives of cyclin-depend...

Inorganic and nuclear chemistry

  • 2020
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  • Jimp
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Result

Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance

Treatment options for hepatocellular carcinoma using chemotherapeutics at intermediate and advanced stages of disease are limited as patients most rapidly escape from therapy and succumb to disease progression. Mechanisms of the hepatic xenobiotic me...

FR - Farmakologie a lékárnická chemie

  • 2013
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  • Jx
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Result

Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium

Roscovitine is a candidate anticancer drug acting as an inhibitor of cyclin-dependent kinases which are involved in cell-cycle control and in apoptosis triggering. In our present study,we show for the first time that roscovitine yie...

Analytical chemistry

  • 2019
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  • Jimp
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Result

Synthesis and biological evaluation of guanidino analogues of roscovitine

to the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine, has been in the C2 position to roscovitine; this compound displayed approximately five fold, (S)-6-guanidinopurine derivatives were generally more active t...

ED - Fyziologie

  • 2013
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  • Jx
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  • Link
Result

Physiological responses and endogenous cytokinin profiles of tissue-cultured 'Williams' bananas in relation to roscovitine and an inhibitor of cytokinin oxidase/dehydrogenase (INCYDE) treatments

) requiring cultures with roscovitine (6-benzylamino-2-[1(R)-(hydroxymethyl)propyl]amino-9 (93 %) was observed in BA + roscovitine while mT + INCYDE plantlets produced most shoots. Treatment with BA + roscovitine h...

EB - Genetika a molekulární biologie

  • 2012
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  • Jx
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Result

Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity

in cellular and biochemical assays. 7-Benzylamino-5(R)-[2-(hydroxymethyl)-propyl]amino-3 of the well-known CDK inhibitor roscovitine. An X-ray crystal structure of compound 7 to that of roscovitine. Protein kinase selectiv...

CE - Biochemie

  • 2011
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  • Jx
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  • 1 - 10 out of 18 835