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Molecular Profiling of Hyalinizing Clear Cell Carcinomas Revealed a Subset of Tumors Harboring a Novel EWSR1-CREM Fusion Report of 3 Cases
We describe a novel gene fusion, EWSR1-CREM, identified in 3 cases of clear polymerase chain reaction demonstrated a EWSR1-CREM fusion in all 3 cases to confirm a diagnosis of CCC. This finding is biologically justified as CREM<...
Pathology
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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A novel SMARCA2-CREM fusion expending the molecular spectrum of salivary gland hyalinazing clear cell carcinoma beyond the FET genes
involving EWSR1 (22q12.2) leading to two fusion genes EWSR1::ATF1 or EWSR1::CREM. We report one case of HCCC with a novel SMARCA2::CREM fusion, identified by targeted RNA in salivary glands. The exon 4 of SMARCA2 is fused to exon 5...
Pathology
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Control of Synthetic Feasibility of Compounds Generated with CReM
chemically reasonable mutations approach (CReM) and the ways how one could indirectly complexity and target scores and demonstrated that CReM-based solutions were competitive......
Biochemistry and molecular biology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
What are present directions of stress research
stres, návykové látky, CREM...
ED - Fyziologie
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Transection of central and peripheral nerve fibers selectively affect the expression and phosphorylation of CREB, CREM and SRF proteins in axotomized neurons.
Annotation not available...
FA - Kardiovaskulární nemoci včetně kardiochirurgie
- 1994 •
- D
Rok uplatnění
D - Stať ve sborníku
MITF::CREM-rearranged tumor: a novel group of cutaneous tumors with melanocytic differentiation
include MITF::CREM fusion-associated tumors, but the available data are limited only MITF::CREM gene fusion. There had no evidence of disease 9 months after......
Pathology
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Update on cutaneous mesenchymal tumors in the 5th edition of WHO classification of skin tumors with an emphasis on new fusion-associated neoplasms
, and MITF::CREM genes as well as EWSR1::SMAD3-rearranged fibroblastic tumors...
Pathology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
CReM: chemically reasonable mutations
CReM is an open-source Python framework to generate chemical structures using a fragment-based approach. It uses historical data about previously synthesized compounds (e.g. ChEMBL) to generate new ones. Known molecules are exhaustively frag...
Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
- 2020 •
- R •
- Link
Rok uplatnění
R - Software
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Mesenchymal skin tumors – Novel entities in the 5th edition of WHO classification of skin tumors
, and MITF::CREM genes. In addition, EWSR1::SMAD3-rearranged fibroblastic tumors...
Pathology
- 2024 •
- JSC •
- Link
Rok uplatnění
JSC - Článek v periodiku v databázi SCOPUS
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CReM: chemically reasonable mutations framework for structure generation
The drug-like chemical space is vastly enormous—its size estimates in ~ 1033 compounds [1]. In the nearest future, it will be impossible to enumerate this space or perform any kind of exhaustive search. Therefore, methods and strategies to explore th...
Biochemistry and molecular biology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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