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20 522 (0,155s) •

Result

Lincosamides, preparation and use thereof

The present invention relates to novel hybrid lincosamides, their preparation using the enzymatic activities from celesticetin biosynthesis, and their use as antimicrobial and antiprotozoal agents....

Cell biology

  • 2018
    • •
  • P
    • •
  • Link
Result

Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database

(CLE) and the efficacy of antimalarial agents. Objectives To investigate the influence of smoking on disease severity and antimalarial treatment in patients with CLE Index (CLASI) and the efficacy of antimalarial ...

FO - Dermatovenerologie

  • 2014
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  • Jx
    • •
  • Link
Result

Use of antimalarials in dermatology

The author gives on overview of current knowledge regarding the use of antimalarials in dermatology. Common antimalarial drugs include chloroquine, hydroxychloroquine and quinacrine. Antimalarials, mainly chloroquine and hy...

Dermatology and venereal diseases

  • 2017
    • •
  • JSC
Result

Synthesis and biological activity of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]-N-phenylacetamide derivatives as antimalarial and cytotoxic agents

Malaria is a mosquito-transmitted (female Anopheles) infectious disease caused by Plasmodium parasites. Five parasite species can cause malaria in humans. In particular, Plasmodium falciparum and Plasmodium vivax are the most dangerous. Around 219 mi...

Biochemistry and molecular biology

  • 2020
    • •
  • Jimp
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  • Link
Result

Antimalarial Prophylaxis in Travelers to Malaria Risk Areas

Malaria is one of the most common diseases imported to the Czech Republic with an upward trend in incidence. Travelers are leaving for abroad without antimalarial prophylaxis or refuse preventive antimalarial drugs. Failure to compl...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013
    • •
  • Jx
Result

The Role of Acyclic Nucleoside Phosphonates as Potential Antimalarials

Acyclic nucleoside phosphonates (ANPs) are a recognized class of antiviral and anticancer agents. Since the discovery of ANPs in the mid-1980s, ANPs have gained recognition in pharmaceutical research. Approvals of cidofovir (Vistide (R)) in ...

CC - Organická chemie

  • 2014
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  • Jx
Result

A comprehensive structural analysis of new antimalarial derivatives using chiroptical and vibrational spectoscopy

and their stereochemistry not only affects antimalarial activity [2, 3] but also leads to different that the efficacy of most antimalarials is compromised by theemergence of Plasmodium species resistant to available antimalaria...

Analytical chemistry

  • 2023
    • •
  • O
Result

As Antimalarial Agents

Hypoxanthineguanine[xanthine] phosphoribosyltransferase (HG[X]PRT) is considered an important target for antimalarial chemotherapy as it is the only pathway for the synthesis of the purine nucleoside monophosphates required for DNA/RNA produ...

CC - Organická chemie

  • 2015
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  • Jx
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  • Link
Result

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogues as potential antimalarial agents

Iso-HPMPHx and iso-HPMPG were found as effective inhibitors of both the Pf and Pv enzymes HGXPRT. iso-HPMPHx shows the highest selectivity. A series of side-chaim modified analogues of both compounds was also prepared....

CC - Organická chemie

  • 2012
    • •
  • Jx
    • •
  • Link
Result

6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs

Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates....

CC - Organická chemie

  • 2011
    • •
  • Jx
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