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Binding of Kingella kingae RtxA Toxin Depends on Cell Surface Oligosaccharides, but Not on beta(2) Integrins
some other cytotoxins of the RTX family, K. kingae RtxA does not bind target cells infections. K. kingae secretes an RtxA toxin that belongs to a broad family of the RTX (Repeats in ToXin) cytotoxins produced by b...
Microbiology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Kingella kingae RtxA toxin interacts with sialylated gangliosides
The membrane-damaging RTX family cytotoxin RtxA is a key virulence factor of RtxA binding to host cells. While we have previously shown that RtxA binds cell of gangliosides. The recognition of gangliosides by R...
Microbiology
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Kingella kingae RtxA Cytotoxin in the Context of Other RTX Toxins
endocarditis. K. kingae secretes an RtxA cytotoxin, which is involved in the development secretion signal recognized by the type I secretion system. RTX toxins, including RtxA of bacterial infections. RtxA was dis...
Microbiology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Two pairs of back-to-back alpha-helices of Kingella kingae RtxA toxin are crucial for the formation of a membrane pore.
The RtxA cytotoxin, a member of the RTX (Repeats in ToXin) family of pore unknown. Here, we used labelling of cell-bound RtxA with a membrane-impermeable is localised extracellularly. A trypsin protection assay with cell-bo...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Two pairs of back-to-back α-helices of Kingella kingae RtxA toxin are crucial for the formation of a membrane pore
The RtxA cytotoxin, a member of the RTX (Repeats in ToXin) family of pore unknown. Here, we used labelling of cell-bound RtxA with a membrane-impermeable is localised extracellularly. A trypsin protection assay with cell-bo...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding
secretes a membrane-damaging RTX (Repeat in ToXin) toxin, RtxA, which is implicated in the development of clinical infections. However, the mechanism by which RtxA recognizes of RtxA, we have developed a procedure for the ...
Microbiology
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins
), andKingella kingaecytotoxin (RtxA). We found that the three protoxins are acylated assays revealed that RtxA has to be modified by 14-carbon fatty acyl chains......
Biochemistry and molecular biology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Integrin Subunit CD18 Is the T-Lymphocyte Receptor for the Helicobacter pylori Vacuolating Cytotoxin
Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. Here, we show that VacA efficiently enters activated prim...
EE - Mikrobiologie, virologie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Vero cytotoxin VT2e producing Escherichia coli strain.
Base of the patennt is new vero cytotoxin VT2e producing Escherichia coli strain CAPM 6437 suitable for production of the verocytotoxin to production of the vaccine against oedema disease of piglets after weaning....
GJ - Choroby a škůdci zvířat, veterinární medicina
- 2012 •
- P
Rok uplatnění
P - Patent
Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity
related microbes produce the enterotoxins tilimycin and tilivalline; cytotoxin demonstrate that carbohydrates induce cytotoxin synthesis while concurrently repressing indole biosynthesis. Conversely, indole represses cytotoxin<...
Microbiology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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