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13 941 (0,088s) •

Result

Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC

-tetrahydrocannabinol (THC) and cannabidiol (CBD) are influenced by dose and administration route (sc.) THC, CBD and THC+CBD. Concentrations of THC, its metabolites 11-OH-THC and...

Clinical neurology

  • 2017
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  • Jimp
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  • Link
Result

Pharmacokinetic and behavioural profile of THC, CBD, and THC plus CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC

-tetrahydrocannabinol (THC) and cannabidiol (CBD) are influenced by dose and administration route (sc.) THC, CBD and THC+CBD. Concentrations of THC, its metabolites 11-OH-THC and...

Neurosciences (including psychophysiology)

  • 2017
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  • Jimp
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  • Link
Result

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain

of the endocannabinoid system modulator delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD A (167received THC/CBD spray and 172 received placebo). Of those who completed phase A, 58 on THC/CBD s...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013
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  • Jx
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  • Link
Result

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

. Psychoactive delta-9-tetrahydrocannabinol (THC) and nonpsychoactive cannabidiol (CBD for the analgesic effect of THC, while CB2 receptors may account for its immunomodulatory properties. Unlike THC, CBD ...

Pharmacology and pharmacy

  • 2022
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  • Jimp
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  • Link
Result

CBD is not converted to THC in rats: A framework interpretation and discussion

Cannabidiol (CBD) is a non-psychotropic exogenous cannabinoid that is an active component in a number of topical and oral preparations. The pharmacological potential of CBD is determined by its anti-inflammatory and immuno- or neuro...

Pharmacology and pharmacy

  • 2021
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  • JSC
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  • Link
Result

Perspectives of cannabis-based medicines in a view of pharmacokinetic studies of Δ9-THC and CBD in humans

(phytocannabinoids, PCs), i.e., Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD cannabis with dominant content of Δ9-THC or CBD or equal composition of both PCs applications of Δ9-THC and CBD

Pharmacology and pharmacy

  • 2025
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  • JSC
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  • Link
Result

CBD enhances the cognitive score of adolescent rats prenatally exposed to THC and fine-tunes relevant effectors of hippocampal plasticity

cannabidiol (CBD) as a rescue strategy to temper prenatal THC-induced harm. Methods: To this aim, Wistar rats prenatally exposed to THC (2 mg/kg s.c.) or vehicle (gestational: While this research shows CBD potenti...

Pharmacology and pharmacy

  • 2023
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  • Jimp
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  • Link
Result

A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment

(THC/CBD) oromucosal spray, a novel cannabinoid formulation, was investigated were randomized to THC/CBD spray and 118 to placebo, in addition to their current statistically significant treatment differences in fa...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014
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  • Jx
Result

A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain

Peripheral neuropathic pain (PNP) poses a significant clinical challenge. The long-term efficacy of delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray was investigated in this 38-week open-label extension study. I...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015
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  • Jx
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  • Link
Result

The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer's Disease

, attention is paid to two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). With respect to the psychotropic effects and dependence potential of THC (though it is very mild), its use is associate...

Biochemistry and molecular biology

  • 2023
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  • Jimp
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  • Link
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