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Editorial: Current understanding of genomic and chromosomal instabilities in solid malignancies
Editorial on the Research Topic: Current understanding of genomic and chromosomal instabilities in solid malignancies.
Oncology
- 2023 •
- O •
- Link
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O - Ostatní výsledky
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Dynamics of telomerw erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemi arising from MDS: a marker of disease prognosis?
telomere erosion, MDS, AML, genome instability, chromosomal aberrations, IPSS risk groups, prognosis of MDS...
EB - Genetika a molekulární biologie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability
Tumors vary widely in chromosomal level genome instability. To gain a better understanding of the underlying defects which foster specific types of aberrations, we investigated the response of cells of related genetic backgrounds to...
BO - Biofyzika
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Dynamics of telomere lenght and its association with genome instability in myelodysplastic syndromes and acute myeloid leukemia arising from MDS
The telomere lenght instability is important factor in conversion MDS to AML...
FD - Onkologie a hematologie
- 2002 •
- C
Rok uplatnění
C - Kapitola v odborné knize
Changes of telomere-telomerase complex are related to genome instability and have a significant meaning in prognosis of conversion of myelodysplastic syndromes toward overt leukemia.
Changes of telomere-telomerase complex are related to genome instability and have a significant meaning in prognosis of conversion of myelodysplastic syndromes toward overt leukemia....
FD - Onkologie a hematologie
- 2002 •
- D
Rok uplatnění
D - Stať ve sborníku
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homol...
Biological sciences
- 2020 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homol...
Biochemistry and molecular biology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Determination of Genomic Imbalances Using Array comparative Genomic Hybridization (Array CGH) in Cancer Genom
Canser is a disease characterized by genomic instability. One of the mechanisms that changes gene expression and gene function is DNA copy number changes. These changes mostly include gains and losses of chromosomal regions, which c...
FD - Onkologie a hematologie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations
induced genomic instability in pre-malignant finite cells may generate the errors passenger errors carried forward into resulting carcinomas, (2) genomic instability normal karyotypes. Most human carcinomas contai...
Cell biology
- 2014 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Genome instability in the context of chromatin structure and fragile sites
We summarized knowledge about genome structure and fragile sites that represent regions of possible gene translocations that are associated with malignant cell transformation. Review is a summary of knowledge on epigenetics and genome
BO - Biofyzika
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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