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Microtubule disruptors and their interaction with biotransformation enzymes
antimitotics are potential culprits of drug-drug interactions on the level of activityMicrotubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic ...
CE - Biochemie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
4-arylazo-3,5-diamino-pyrazole compounds and use thereof
A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK 9). Hence they can be used as antimitotic-, pro-apoptotic and antiinflammatory drugs, in par...
CC - Organická chemie
- 2009 •
- P
Rok uplatnění
P - Patent
Chromosome doubling effects of selected antimitotic agents in Brassica napus microspore culture
. In vitroapplications of all antimitotic drugs increased the rate of doubled haploid (DH) plantsEffects of microspore culture treatment with antimitotic agents colchicine, trifluralin and oryzalin on the frequency of embry...
GE - Šlechtění rostlin
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
4-arylazo-3,5-diamino-pyrazole compounds and use thereof
A series of mono-and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK9). Hence they can be used as antimitotic,pro-apoptotitc and antiinflammatory drugs, in partic...
CC - Organická chemie
- 2013 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Alopecia
follicles and usually commences 2 weeks after treamtnet started. The drugs most likely to cause temporary alopecia are alkylating agents, antibiotic antimitotics and taxanes. Scalp cooling may prevent or retard expected hair loss w...
Oncology
- 2019 •
- O
Rok uplatnění
O - Ostatní výsledky
Recovery of tubulin functions after freeze-dying in the presence of trehalose
We describe a novel method for freeze-drying of assembly-competent tubulin in the presence of a nonreducing sugar trehalose. Even after prolonged storage at ambient temperature, rehydrated tubulin is capable of binding antimitotic drugs<...
EB - Genetika a molekulární biologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Effectiveness of selected antimitotic agents for embryogenesis in Brassica carinata microspore culture
The effect of antimitotic agents colchicine, trifluralin and oryzalin on isolated microspore culture Brassica carinata was evaluated in order to combine a positive effect of antimitotic agents on the induction of embryogenesis with ...
GE - Šlechtění rostlin
- 2007 •
- D
Rok uplatnění
D - Stať ve sborníku
New heterocyclic compounds with strong CDK inhibitory and anticancer properties.
effects. Hence they can be used as antimitotic drugs, in particular, in chemotherapy selectivity for some CDKs, or (3) an increased antimitotic activity at the G1/S and G2/M, treatment of Alzheimer´s disease or as antineur...
ED - Fyziologie
- 2004 •
- D
Rok uplatnění
D - Stať ve sborníku
The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin
Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site...
BO - Biofyzika
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Colchicine
Colchicine is an antimitotic poison, an alkaloid extracted from autumn crocus. Most importantly, it is indicated as drugs of choice in acute gouty attacks. It can also be used in lower doses for long term treatment of chronic gout a...
Rheumatology
- 2017 •
- Jost •
- Link
Rok uplatnění
Jost - Ostatní články v recenzovaných periodicích
Výsledek na webu
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