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Results

97 results (1,18s)

Result

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1

and 1A2. Using site-directed mutagenesis we investigated the possible mechanisms of CYP1A1/1A2/1B1-catalyzed AAI nitroreduction. Molecular modelling predicted that the hydroxyl groups of serine122/threonine124 (Ser122/Thr1...

CE - Biochemie

  • 2016
  • Jx
  • Link
Result

Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1

of the differences in mechanistic details of CYP1A1-, 1A2-, and 1B1- mediated reduct importance. Human cytochrome P450 (CYP) 1A1 and 1A2 enzymes were found to be responsible......

CE - Biochemie

  • 2012
  • Jx
Result

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5

, followed by CYP2D6 > 2C19 > 1B1 > 1A2 > 2E1 and >2C9. Cytochrome b5 increased formation of this metabolite by human CYPs, predominantly by CYP1A1, 3A4, 1A2 and 2C19. Formation of 12 to this metabolite (CYP1A1, 1A2

CE - Biochemie

  • 2012
  • Jx
  • Link
Result

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers

CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed-derived DNA adduct formation, were mainly formed by CYP1A1 and 1B1, and to a lesser of BaP, was formed by most human CYPs tested, although...

CE - Biochemie

  • 2016
  • Jx
  • Link
Result

Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes

activities of CYP1A1, 1A2 and 1B1 in hepatic microsomes. Thus, BaP genotoxicity in rats and 1B1 together with microsomal epoxide hydrolase. The azo dye Sudan I is a potent CYP1A1/2 and 1B1 caused by exposure of ra...

Biochemistry and molecular biology

  • 2021
  • Jimp
  • Link
Result

Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: A HuGE-GSEC review

Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: A HuGE-GSEC review.

EB - Genetika a molekulární biologie

  • 2007
  • Jx
Result

The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver

the effectof St John?s wort on the activity of cytochrome P450 1A2. The isolated perfused for cytochrome P450 1A2. The rate of formation of acetaminophen was significantly inhibitedby P450 1A2 activity significantly more t...

FR - Farmakologie a lékárnická chemie

  • 2011
  • Jx
  • Link
Result

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans....

CE - Biochemie

  • 2005
  • Jx
Result

Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin

enzymes revealed that human sulfotransferases (SULTs) 1A1*1, 1A1*2, 1A2, 1A3, 1B1, 1C4, and that SULTs 1A1, 1A3, 1B1, and 1E1 could be involved in the biotransformation......

Microbiology

  • 2020
  • Jimp
  • Link
Result

Frost-Hardiness prediction of Common Wheat Using Gliadin Genetic Markers

and newly also Gld 1B1 and Gld 6A1 can be considered as secondary markers. Markering efficiency of Gld 1-1A2 was not proved and occurrence......

EB - Genetika a molekulární biologie

  • 2000
  • Jx
  • 1 - 10 out of 97