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Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
and 1A2. Using site-directed mutagenesis we investigated the possible mechanisms of CYP1A1/1A2/1B1-catalyzed AAI nitroreduction. Molecular modelling predicted that the hydroxyl groups of serine122/threonine124 (Ser122/Thr1...
CE - Biochemie
- 2016 •
- Jx •
- Link
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Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1
of the differences in mechanistic details of CYP1A1-, 1A2-, and 1B1- mediated reduct importance. Human cytochrome P450 (CYP) 1A1 and 1A2 enzymes were found to be responsible......
CE - Biochemie
- 2012 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5
, followed by CYP2D6 > 2C19 > 1B1 > 1A2 > 2E1 and >2C9. Cytochrome b5 increased formation of this metabolite by human CYPs, predominantly by CYP1A1, 3A4, 1A2 and 2C19. Formation of 12 to this metabolite (CYP1A1, 1A2
CE - Biochemie
- 2012 •
- Jx •
- Link
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Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers
CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed-derived DNA adduct formation, were mainly formed by CYP1A1 and 1B1, and to a lesser of BaP, was formed by most human CYPs tested, although...
CE - Biochemie
- 2016 •
- Jx •
- Link
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Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes
activities of CYP1A1, 1A2 and 1B1 in hepatic microsomes. Thus, BaP genotoxicity in rats and 1B1 together with microsomal epoxide hydrolase. The azo dye Sudan I is a potent CYP1A1/2 and 1B1 caused by exposure of ra...
Biochemistry and molecular biology
- 2021 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: A HuGE-GSEC review
Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: A HuGE-GSEC review.
EB - Genetika a molekulární biologie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver
the effectof St John?s wort on the activity of cytochrome P450 1A2. The isolated perfused for cytochrome P450 1A2. The rate of formation of acetaminophen was significantly inhibitedby P450 1A2 activity significantly more t...
FR - Farmakologie a lékárnická chemie
- 2011 •
- Jx •
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The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen
Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans....
CE - Biochemie
- 2005 •
- Jx
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Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin
enzymes revealed that human sulfotransferases (SULTs) 1A1*1, 1A1*2, 1A2, 1A3, 1B1, 1C4, and that SULTs 1A1, 1A3, 1B1, and 1E1 could be involved in the biotransformation......
Microbiology
- 2020 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Frost-Hardiness prediction of Common Wheat Using Gliadin Genetic Markers
and newly also Gld 1B1 and Gld 6A1 can be considered as secondary markers. Markering efficiency of Gld 1-1A2 was not proved and occurrence......
EB - Genetika a molekulární biologie
- 2000 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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