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Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Reported is the identification of the furo[3,2-b]pyridine core as a novel couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated[3,2-b<...
Analytical chemistry
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Reported is the identification of the furo[3,2-b]pyridine core as a novel couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated[3,2-b<...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core
The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-
Pharmacology and pharmacy
- 2021 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Furopyridines as inhibitors of protein kinases
The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing th...
Organic chemistry
- 2018 •
- P •
- Link
Rok uplatnění
P - Patent
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Furopyridines as inhibitors of protein kinases
The invention relates to furo[3,2- b ]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing ...
Organic chemistry
- 2020 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Furopyridines as inhibitors of protein kinases
The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing th...
Organic chemistry
- 2018 •
- P •
- Link
Rok uplatnění
P - Patent
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2-[3-(Trifluoromethyl)phenyl]furo[3,2-b]pyrroles:Synthesis and Reactions
-(trifluoromethyl)phenly]-4H-furo[3,2-b]pyrrole-5-carboxylic acid (2a) in acetic anhydride, 4-acetyl-2-[3-(trifluoromethyl)phenyl]furo[3,2-b]pyrrole (4) was formed. By hydrolysis of 4, 2[3-(triflu...
CC - Organická chemie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Substituted furo[3,2-b]pyridines intended for use as medicaments
The present invention provides substituted furo[3,2-b]pyridines of the general formula I or pharmaceutically acceptable salts or solvates thereof, wherein Re1 represents phenyl or naphthyl, being optionally substit...
CC - Organická chemie
- 2015 •
- P
Rok uplatnění
P - Patent
Crystal structure, spectroscopic and magnetic properties, and antimicrobial activities of cobalt(II) 2-methylthionicotinate complexes with N -heterocyclic ligands
-methylnicotinamide-N-Menia, furo[3,2-c]pyridine-fpy, 2,3-dimethylfuro[3,2-c]pyridine-Me2fpy or benzo[4,5]furo[3,2-c]pyridine-Bfp; n is 0, 1 or 2) as well as [Co(2-MeSnic)2L2] (L...
CA - Anorganická chemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Convenient Synthesis of Furo[3,2-b]quinolin-4(1H)-ones
In this work, we report the simple synthesis of furo[3,2-b]quinolin-4(1H)-ones from readily available 4-ethynyl-[1,3]dioxolo[4,5-c]quinolone as the key starting material. After Sonogashira (hetero)arylation, formation of th...
Organic chemistry
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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