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105 849 (0,313s)

Result

Human leukocyte antigens

Leukocyte antigens class I and II (HLA I and II) are expressed on leukocyte membranes. This chapter deals with HLA polymorphisms, their inheritance, significance in immune system, in transplantology transplant and as well d...

FD - Onkologie a hematologie

  • 2013
  • C
Result

HLA association with diseases

HLA system represents the human major histocompatibility complex (MHC), which encodes a large complex genes determining surface molecules (antigens) located area of the human genome, particularly by studying the MHC complex HLA gene...

FD - Onkologie a hematologie

  • 2015
  • C
  • Link
Result

Next-generation sequencing based HLA typing: deciphering immunogenetic aspects of sarcoidosis

is complex due to the extensive HLA polymorphism and strong linkage-disequilibrium and to attribute a causal role to specific HLA alleles/haplotypes in disease susceptibility of several immune disorders in which <...

Human genetics

  • 2018
  • Jimp
  • Link
Result

Association between sarcoidosis and HLA polymorphisms in a Czech population from Central Europe: focus on a relationship with clinical outcome and treatment

are associated with more advanced disease represented by the CXR stages 2-4. HLA-DQB1*05:03 aiming to define how variation in HLA genes, may contribute to disease origin, HLA-DQA1*05:01, and ...

General and internal medicine

  • 2023
  • Jimp
  • Link
Result

The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech

the predisposition to both diseases. We tested on an association of HLA-Cw allelesand functional population. We found a statistically significant association between HLA-Cw*06 allele subtype (P (corrected...

EB - Genetika a molekulární biologie

  • 2013
  • Jx
  • Link
Result

HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population

Psoriatic arthritis (PsA) is a chronic inflammatory joint disease which affects patients suffering from psoriasis. The genetic background especially the susceptibility loci on the short arm of the chromosome six contribute to PsA development...

EB - Genetika a molekulární biologie

  • 2009
  • Jx
Result

HLA DRB1,DQB1 and insulin promoter VNTR polymorphisms:interactions and the association with adult-onset diabetes mellitus in Czech patiens

the association between each of these polymorphisms and DM diagnosed in patients older than age 35 years. Furthermore, we analysed possible interactions between HLA BRB1/DQB1Both the human leucocyte antigen (HLA) ...

FE - Ostatní obory vnitřního lékařství

  • 2008
  • Jx
Result

HLA class II variants defined by Next Generation Sequencing are associated with sarcoidosis in Korean patients

for multiple comparisons. Variants previously associated with sarcoidosis risk (HLA-C*03:04, were associated with sarcoidosis in Koreans. Further, we suggest new HLA variants associated with sarcoidosis r...

Respiratory systems

  • 2022
  • Jimp
  • Link
Result

Association of HLA variants and related SNPs with sarcoidosis and its phenotypes in the Greek patients

and investigated associations between sarcoidosis and HLA alleles, including HLA-related singleSarcoidosis is an immune-mediated disease, characterized by the formation, multifactorial condition, both environmenta...

Genetics and heredity (medical genetics to be 3)

  • 2024
  • Jimp
  • Link
Result

HLA-DPB polymorphisms: Glu 69 association with sarcoidosis

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1996
  • Jx
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