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Preparing unbiased T cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling
High throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitat...
EB - Genetika a molekulární biologie
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
High-quality full-length immunoglobulin profiling with unique molecular barcoding
High-throughput sequencing analysis of hypermutating immunoglobulin (IG) repertoires remains a challenging task. Here we present a robust protocol for the full-length profiling of human and mouse IG repertoires. Th...
CE - Biochemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ to the WHO classification. The most striking Ig gene repertoire skewing was observed, particularly ENMZL, with significantly different <...
Oncology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications
the ontogeny of G-CLL versus MD-CLL by profiling the relevant IG gene repertoires and 169 expressed IG mu/delta and gamma heavy chains, respectively. Results: G-CLL has a highly skewed IG gene repertoire ...
FD - Onkologie a hematologie
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Antibody repertoire development in fetal and neonatal piglets.VI. B cell lymphognesis occurs at multiple sites with differences in the frequency of in-frame rearrangements.
Differentiation of B cell precursors from multipotent stem cells to immature B cells is characterized by the status of Ig gene rearrangement and the expression of certain genes....
EE - Mikrobiologie, virologie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges
Analysis and interpretation of Ig and TCR gene rearrangements) technologies, a deeper analysis of Ig and/or TCR (IG/TR) gene rearrangements is now within reach, which impacts on all main applications of IG/TR immun...
Immunology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting
Secondary diversification of the Ig repertoire occurs through somatic Ig genes at orders of magnitude higher than the rest of the genome, but the basis and enhancer-like sequences from Ig genes are capable of stimu...
Immunology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements
Immunoglobulin (IG) gene repertoire restrictions strongly support antigen-generation sequencing (NGS) study of the T-cell repertoire, focusing on major stereotyped patients carrying non-subset IG rearrangements to ...
Oncology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
tcR: an R package for T cell receptor repertoire advanced data analysis
Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key cell receptor repertoire profiling. However, a specialised software is required analysis of T cell receptor repertoires, which includes diversit...
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Antibody repertoire development in fetal and neonatal piglets. XX. B cell lymphogenesis is absent in the ileal Peyer´s patches, their repertoire development is antigen dependent
of mammalian bursal equivalent where B cells diversify their repertoire in an Ag. Resection of 90%of the IPP in piglets at birth did not alter Ig levels in serum and secretions or retard diversification of the Ab repertoire
EC - Imunologie
- 2011 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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