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Structural analysis of phosphatidylinositol 4-kinase III beta (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro
Phosphatidylinositol 4-kinase III beta (PI4KB) is responsible for the synthesis lipid and as a precursor for higher phosphoinositides. In addition, PI4KB of this enzyme in cells, it has to be regulated. 14-3-3 proteins bind PI4K...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein
Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes be recruited to the correct membrane compartment. PI4KB is critical for the maintenance mechanism of PI4KB to the Golgi and TGN membranes is unkno...
EE - Mikrobiologie, virologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase III beta (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology
Phosphatidylinositol 4-kinase III beta (PI4KB) is indispensable to the arrest of viral replication. Here, we report On the synthesis of novel PI4KB of inhibitors that bind in the ATP binding side of PI4KB. These ”hybrids” n...
Organic chemistry
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase III beta (PI4KB)
The lipid kinase phosphatidylinositol 4-kinase III beta (PI4KB) is an essential host factor for many positive-sense single-stranded RNA (+RNA) viruses including), coxsackie viruses, and rhinoviruses. Inhibitor of PI4KB are considere...
Organic chemistry
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Phosphatidylinositol 4-kinase III beta (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins
Phosphatidylinositol 4-kinase III beta (PI4KB) is a key enzyme of the Golgi system because it produces its lipid hallmark the phosphatidylinositol 4-phosphate GTPase Rab11. Here, we analyzed the protein complexes formed by PI4KB in ...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß
inhibits phosphatidylinositol 4‐kinase IIIβ (PI4KB) and suppresses GLI‐mediated. Therefore, inhibition of PI4KB and, consequently, reduction in phosphatidyl‐4‐phosphate......
Organic chemistry
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation
and bound to a phosphopeptide derived from human PI4KB ( phosphatidylinositol 4-kinase B...
CE - Biochemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Structural insights into Acyl-coenzyme A binding domain containing 3 (ACBD3) protein hijacking by picornaviruses
Many picornaviruses hijack the Golgi resident Acyl-coenzyme A binding domain containing 3 (ACBD3) protein in order to recruit the phosphatidylinositol 4-kinase B (PI4KB) to viral replication organelles (ROs). PI4KB, once recruited a...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases
Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for norma...
Biochemistry and molecular biology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Negative charge and membrane-tethered viral 3B cooperate to recruit viral RNA dependent RNA polymerase 3D(pol)
the proper intracellular cofactors (PI4KB and ACBD3). However, our bio-mimetic in vitro...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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