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Osh6 Revisited: Control of PS Transport by the Concerted Actions of PI4P and Sac1 Phosphatase
the transport of all potential ligands of Osh6. PI4P and PS are the best described lipid. So far, it was the exchange between the two cargo molecules, PS and PI4P the gradient without the help of PI4P and that PI4P
Biochemistry and molecular biology
- 2021 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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PI(4,5)P-2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites
(PI4P)/phosphatidylserine (PS) transfer activity of the endoplasmic reticulum (ER)-resident ORP5 and ORP8 is regulated by both PM PI4P and PI(4,5)P-2. Dynamic control Pleckstrin homology domains and adjacent basic residues of ORP5/...
Biochemistry and molecular biology
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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Crystal Structure of the ORP8 Lipid Transport ORD Domain: Model of Lipid Transport
computer simulations based on our crystal structure to dock PS and PI4P molecules transport efficiencies for PS and PI4P, with the lid slowing down transport......
Biochemistry and molecular biology
- 2023 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design
Phosphatidylinositol 4-phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4-kinases (PI4Ks) that synthesize PI4P, among which are PI4K II beta and PI4K II alpha. In ...
CE - Biochemie
- 2015 •
- Jx •
- Link
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Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Phosphatidylinositol 4-kinases: Function, structure, and inhibition
The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the membranes of Golgi and trans-Golgi network (TGN) and regulates trafficking ...
CC - Organická chemie
- 2015 •
- Jx •
- Link
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Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein
Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential regulatory lipid found in all eukaryotic cells. To convert their lipid substrates, PI4K...
EE - Mikrobiologie, virologie
- 2016 •
- Jx •
- Link
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Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes
-phosphate (PI4P), phosphatidic acidic (PA), and phosphatidylserine (PS) are separately along the endocytic pathway and is controlled by PS/PI4P combination. Altogether, we......
Cell biology
- 2018 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Coordination of transporter, cargo, and membrane properties during non-vesicular lipid transport
membrane, where it is exchanged for phosphatidylinositol-4 phosphate (PI4P). PI4P...
Biochemistry and molecular biology
- 2024 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Structural analysis of phosphatidylinositol 4-kinase III beta (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro
Phosphatidylinositol 4-kinase III beta (PI4KB) is responsible for the synthesis of the Golgi and trans-Golgi network (TGN) pool of phosphatidylinositol 4-phospahte (PI4P). PI4P is the defining lipid hallmark of Golgi and TGN and als...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
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Jimp - Článek v periodiku v databázi Web of Science
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Negative charge and membrane-tethered viral 3B cooperate to recruit viral RNA dependent RNA polymerase 3D(pol)
Most single stranded plus RNA viruses hijack phosphatidylinositol 4-kinases (PI4Ks) to generate membranes highly enriched in phosphatidylinositol 4-phosphate (PI4P). These membranous compartments known as webs, replication factories reconsti...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
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