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PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development
The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defect...
Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
GATA-1-mediated regulation of PU.1 gene among different erythroleukemias
GATA-1 binds to PU.1 gene regulatory regions and modulates PU.1 gene expression in human erythroleukemia cell lines OCI-M2 and K562. PU.1 gene regulation in erythroleukemia includes epige...
EB - Genetika a molekulární biologie
- 2014 •
- A
Rok uplatnění
A - Audiovizuální tvorba
Delineating aggressiveness of acute myeloid leukemia in a mouse model carrying mutations of Spi1 (PU.1) and Trp53
PU.1 downregulation within haematopoietic stem and progenitor cells (HSPCs with homozygous deletion of the upstream regulatory element (URE) of PU.1 gene. p53 is a well-/- progenitors express significantly lower
FD - Onkologie a hematologie
- 2014 •
- O
Rok uplatnění
O - Ostatní výsledky
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
This review summarizes the indispensable requirement of transcription factor PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein?protein interactions with addition...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene: Candidate Mechanism of Epigenetic Repression of PU.1 and Inefficient Erythropoiesis in MDS.
GATA-1 binds and represses PU.1 gene during early erythroid differentiation, however this is likely not fully completed in MDS and therefore erythroid differentiation is not efficient. Distribution of chromatin marks along ...
EB - Genetika a molekulární biologie
- 2013 •
- A
Rok uplatnění
A - Audiovizuální tvorba
PU.1 Activation Relieves GATA-1-Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation
Manuscript describes specific mechanisms involving hematopoietic transcription factors PU.1 and GATA-1 during induced leukemia differentiation and contribute potentially to a concept for future biological " leukemia differe...
FD - Onkologie a hematologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Electronic properties of Pu19Os simulating beta-Pu: the strongly correlated Pu phase
of states at the Fermi level points to a higher value, 55 +/- 2 mJ (mol Pu K-2)(-1), compared to 40 mJ (mol K-2)(-1) for delta-Pu. The results confirm that beta-Pu gamma-value of 74 +/- 2 mJ (mol Pu
Condensed matter physics (including formerly solid state physics, supercond.)
- 2018 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia
GATA-1 and PU.1 are two important hematopoietic transcription factors or myeloid lineage, respectively. PU.1 controls its own expression during myelopoiesis (AML). We herein present evidence that GATA-...
FD - Onkologie a hematologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Retrospective determination of Pu-238, Pu-239,Pu-240 and Sr-90 activities in the outer bark of Norway spruce (Picea abies (L.) Karst.) collected at various sites in the Czech Republic
and vertical distribution of Pu-238, Pu-239,Pu-240 and Sr-90 in forest soil. The median activity concentration of Pu-238 in the spruce bark samples was 0.009 Bq kg(-1). The median activity concentration o...
DI - Znečištění a kontrola vzduchu
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Oncogenic microRNA-155 and its target PU.1: an integrative gene expression study in six of the most prevalent lymphomas
The transcription factor PU.1 and its inhibitory microRNA-155 (miR-155) are important regulators of B-cell differentiation. PU.1 downregulation coupled outcomes. We studied expression of miR-155 and PU.
FD - Onkologie a hematologie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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