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Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications
Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining enzymes is also regulated by VDR, therefore it is clinica...
Pharmacology and pharmacy
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Vitamin D receptor regulates TGF-beta signalling in systemic sclerosis
We characterize VDR as a negative regulator of TGF-β / Smad signaling. Impaired VDR signaling with reduced expression of VDR and decreased levels of its ligand may thus contribute to hyper-active TGF-β signaling and aberran...
FE - Ostatní obory vnitřního lékařství
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Vitamin D receptor (VDR) gene polymorphisms and expression profile influence upon the immunological imbalance in Turner syndrome
(VDR) polymorphisms and/or expression profile. To uncover a possible relationship between VDR genotype and clinical conditions in TS patients, we investigated two functional VDR variants (Cdx-2 and FokI) for allele and gen...
Biological sciences
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Expression and activity of VDR and RXRa in the human choriocarcinoma BeWo and JEG-3 cell lines
Expression and activity of VDR and RXRa was studied in placental BeWo and JEG-3 cells...
FR - Farmakologie a lékárnická chemie
- 2007 •
- D
Rok uplatnění
D - Stať ve sborníku
Paricalcitol (19-nor-) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
Paricalcitol (19-nor-1,25/OH2/D2), a second generation vitamin D receptor (VDR significant immunomodulatory activity, comparable to calcitriol. Both VDR agonists of VDR agonists during DCs differentiation abolished their ca...
EC - Imunologie
- 2011 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Paricalcitol (19-nor-1,25-dihydroxycholecalciferol) and calcitriol (1,25-dihydroxycholecalciferol) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
In this study we show that, in all investigated aspects, paricalcitol retains significant immunomodulatory activity, comparable to calcitriol. Both VDR agonists of VDR agonists during DC differentiation abolished their capacity to b...
FE - Ostatní obory vnitřního lékařství
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines
VitaminDreceptor (VDR) regulates the expression ofmany genes involved studied the expression and activity of VDR and its heterodimerization partner retinoid term placenta. We found that VDR and RXRalfa are localised in the ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
Paricalcitol (19-nor-1,25/OH2/D-2), a second generation vitamin D receptor (VDR significant immunomodulatory activity, comparable to calcitriol. Both VDR agonists of VDR agonists during DC differentiation abolished their ca...
EC - Imunologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Assessment of endocrine disruption potential of essential oils of culinary herbs and spices involving glucocorticoid, androgen and vitamin D receptors
of glucocorticoid receptor (GR), androgen receptor (AR) and vitamin D receptor (VDR). Using augmentation of calcitriol- dependent VDR activity was caused by EOs of ginger, thyme, coriander and lemongrass. Mixed antiglucocorticoid a...
Biochemistry and molecular biology
- 2018 •
- JSC •
- Link
Rok uplatnění
JSC - Článek v periodiku v databázi SCOPUS
Výsledek na webu
Plasmid IMG-07-VDR
Expression plasmid encoding a fusion recombinant nuclear receptor VDR for cell-based reporter assays. The coding sequence consists of the DNA binding domain of the yeast transcription factor Gal4 followed by a ligand binding domain of the hu...
Biochemistry and molecular biology
- 2014 •
- Gfunk
Rok uplatnění
Gfunk - Funkční vzorek
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