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32 439 (0,128s) •

Result

Detection of abasic sites in DNA by electrochemical, immunoelectrochemical and acoustic methods using OsO4, 2,2,-bipyridine as a probe for unpaired thymine residues

Electrochemical, immunoelectrochemical and acoustic methods were applied in detection of DNA damage, in our case modeled by presence of abasic sites in short oligodeoxynucleotides of known sequence. Using complex of osmium tetroxide...

BO - Biofyzika

  • 2009
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  • Jx
Result

Radiation affects binding of Fpg repair protein to an abasic site containing DNA

The effect of ionizing radiation to a complex between a DNA duplex containing an analogue of an abasic site (the 1,3- propanediol site) and a mutated Lactococcus lactis Fpg (P1G-L1Fpg) lacking strand cleavage activity has b...

BO - Biofyzika

  • 2004
    • •
  • Jx
Result

Quadruplexes of human telomere dG3(TTAG3)3 sequences containing guanine abasic sites

This study was performed to evaluate how the loss of a guanine base affects the structure and stability of the three-tetrad G-quadruplex of dG3(TTAG3)3, the basic quadruplex-forming unit of the human telomere DNA. The loss of a base is a frequent eve...

BO - Biofyzika

  • 2010
    • •
  • Jx
Result

Thermodynamic Impact of Abasic Sites on Simulated Translesion DNA Synthesis

Loss of a base in DNA and the creation of an abasic (apurinic/apyrimidinic, AP) site is a frequent lesion that may occur spontaneously, or as a consequence calorimetry on the evolution, during primer extension, of a model AP sit...

BO - Biofyzika

  • 2014
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  • Jx
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  • Link
Result

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1

Loss of a base in DNA leading to creation of an abasic (AP) site leaving in the understanding ofthe chemistry and enzymology of abasic DNA largely relies upon the study of AP sites in synthetic duplexes. We report ...

BO - Biofyzika

  • 2015
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  • Jx
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  • Link
Result

Radiolysis of DNA-protein complexes

In the work, modifications of DNA and protein radiolysis due to the interaction of these two partners in specific complexes are discussed. Experimental patterns of frank strand breaks (FSB) and alkali revealed breaks (ARB) obtained for DNA lac operat...

BO - Biofyzika

  • 2005
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  • Jx
Result

Structure and Dynamics of DNA Duplexes Containing a Cluster of Mutagenic 8-Oxoguanine and Abasic Site Lesions

sequence contained an abasic site in the middle of one strand and differedClustered DNA damage sites are caused by ionizing radiation. They are much more difficult to repair than are isolated single lesions, and their biol...

CE - Biochemie

  • 2014
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  • Jx
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  • Link
Result

Adaptation to Alkylation Damage in DNA Measured by the comet Assay.

Adaptation to Alkylation Damage in DNA Measured by the comet Assay...

EB - Genetika a molekulární biologie

  • 2000
    • •
  • Jx
Result

The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex

glycosylase has been known to remove an abasic (Ap) site derived DNA crosslink (Ap-ICL). An Ap-ICL forms spontaneously from the Ap site with an adjacent adenine of the Ap site change crosslink formation in vitro. ...

Biochemistry and molecular biology

  • 2022
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  • Jimp
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  • Link
Result

Probing the Thermodynamics of Incorporation of N-6-methyl-dATP Opposite an Abasic Site, dCMP, and dTMP During Simulated DNA Synthesis by Differential Scanning Calorimetry

Previous reports indicated that when an abasic (apurinic/apyrimidinic, AP) site of N-6-methyl-dATP opposite an AP site, dCMP, and dTMP during simulated DNA polymerization. The results confirm that AP sites block DN...

Biochemistry and molecular biology

  • 2018
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  • Jimp
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  • Link
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