All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Filters

127 537 (0,285s)

Result

Biological activity of triterpenoids: anticancer activity

Biological activity of triterpenoids: anticancer activity...

CC - Organická chemie

  • 2004
  • Jx
Result

Polymeric anticancer drugs with pH-controlled activation

Polymeric anticancer drugs, pH-controlled activation...

EC - Imunologie

  • 2002
  • C
Result

Mechanism of DNA adduct formation by anticancer drug ellipticine activated by cytochromes P450 in vitro and in vivo

The anticancer drug ellipticine is activated by oxidative reaction to species binding to DNA in vitro and in vivo.

CE - Biochemie

  • 2003
  • D
Result

Hydration Process as an Activation of Trans- and Cisplatin Complexes in Anticancer Treatment. DFT and Ab Initio Computational Study of Thermodynamic and Kinetic Parameter

Hydration Process as an Activation of Trans- and Cisplatin Complexes in Anticancer Treatment. DFT and Ab Initio Computational Study of Thermodynamic and Kinetic Parameter......

CF - Fyzikální chemie a teoretická chemie

  • 2005
  • Jx
Result

Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney

The paper describes role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine and additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney....

CE - Biochemie

  • 2010
  • Jx
Result

Sulfur containing acridin derivatives in preclinical studies with cancer cell lines

the anticancer activity of this class of acridine derivatives. Methods: We present into the anticancer activity of acridine derivatives containing sulphur. The evidence of specific on the anticancer a...

Pharmacology and pharmacy

  • 2018
  • Jimp
  • Link
Result

Rat cytochromes P450 are suitable model enzymes mimicking the metabolic activation of anticancer drug ellipticine in humans

Rats are more suitable models than rabbits mimicking the metabolic activation of ellipticine in humans.

CE - Biochemie

  • 2003
  • D
Result

Cytochromes P450 reconstituted with NADPH:P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes

Activation and detoxication of the anticancer drug ellipticine by cytochromes P450 reconstituted with NADPH:P450 reductase...

CE - Biochemie

  • 2006
  • Jx
Result

Utilization of cytochromes P450 to explain a new mechanism of action of anticancer drug ellipticine

Cytochromes P450 activate the anticancer drug ellipticine to the pharmacologically more effictive metabolites binding covalently to DNA in vitro and in vivo....

CE - Biochemie

  • 2003
  • C
Result

Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells

We report design and synthesis of set of novel anticancer agents based on caffeine-hydrazones bearing 2-hydroxyaryl- or 2-N-heteroaryl moiety. Anticancer activity evaluation using seven cancer cell lines and two non-maligna...

CE - Biochemie

  • 2015
  • Jx
  • Link
  • 1 - 10 out of 127 537