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Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest
The transcription factor c-Myc, a key regulator of cellular processes, has long analyses the multiple functions of c-Myc by examining the different c-Myc isoforms in detail. The impact of differen...
Medicinal chemistry
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Kaposi Sarcoma-associated Herpesvirus vIRF-3 Protein Binds to F-box of Skp2 Protein and Acts as a Regulator of c-Myc Protein Function and Stability
. Furthermore, vIRF-3 contributes to KSHV-associated pathogenesis by stimulating c-Myc of the SCFskp2 ubiquitin ligase complex. Skp2 is a transcriptional co-factor for c-Myc that was shownto regulate the stability ...
EE - Mikrobiologie, virologie
- 2012 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Single-cell c-myc gene expression in relationship to nuclear domains
Nuclear locations of the c-myc gene and its transcripts have been investigated in relation to nuclear domains involved in RNA synthesis and processing. C-myc RNA signals were positioned in the most internal parts o...
BO - Biofyzika
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs
Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs - Advanced Therapies 2023, 14-15 March 2023, ExCeL, London conference poster....
Pathology
- 2023 •
- O
Rok uplatnění
O - Ostatní výsledky
Myc 9aaTAD activation domain binds to mediator of transcription with superior high affinity
factors, including c-Myc. The predicted activation function was experimentally coactivator. We showed conservation of the 9aaTADs in the MYC family. In summary for the c function. The c-Myc prote...
Basic medicine
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Shikonin regulates C-MYC and GLUT1 expression through the MST1-YAP1-TEAD1 axis
key regulators of glycolysis, C-MYC and GLUT1, are targets of the Hippo signaling by the natural compound shikonin inhibited the expression of GLUT1 and C-MYC. Furthermore, RNAi experiments confirmed the regulatio...
EE - Mikrobiologie, virologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours
Background: c-MYC is a potent oncoprotein with roles in a wide range of the protein. Here we studied expression of c-MYC in correlation to clinical outcome: Immunohistochemistry was used to identify c-...
Oncology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Nuclear topography of the c-myc gene in human leukemic cells
N/A...
EB - Genetika a molekulární biologie
- 2000 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells
Cytogenetic studies revealed the presence of two chromosomes 8 in HT-29 cells, of which the one containing c-myc gene amplicons was substantially larger and easily distinguished from the normal chromosome. This observation enabled d...
BO - Biofyzika
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Interference of mouse polyomavirus with the c-myc gene and its product in mouse mammary adenocarcinomas
Molecular basis of polyomavirus-induced mammary adenocarcinomas...
EE - Mikrobiologie, virologie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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