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A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid acid I (aristolochic acid Ia, AAIa). We previously investigated the efficiencies and rat...
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver
The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid nephropathy (AAN), Balkan endemic importance. Therefore, the present study has been desig...
CE - Biochemie
- 2011 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo
Aristolochic acid I (AAI) is a natural plant alkaloid causing aristolochic acid cytochrome P450 (CYP) 1A1 and 1A2. Here, we investigated which of these two opposing-DNA adducts was analyz...
CE - Biochemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen
Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues fro...
CE - Biochemie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The Role of Cytochrome P450 Enzymes in Carcinogen Metabolism: Lessons Learned From Studies With Benzo[a]pyrene and Aristolochic Acid
the P450-dependent metabolism, toxicity, and carcinogenicity of two human environmental carcinogens, benzo[a]pyrene (BP) and aristolochic acid I (AAI). This chapter focuses detoxification metabol...
Biochemistry and molecular biology
- 2018 •
- C •
- Link
Rok uplatnění
C - Kapitola v odborné knize
Výsledek na webu
Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: Evidence for its oxidative detoxication by human cytochromes P450
The first report on the metabolism and detoxication of 2-nitroanisole by human P450 enzymes...
CE - Biochemie
- 2004 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Cancerogenic and nephrotoxic aristolochic acids are activated by human cytochromes P450 1A1 and 1A: study on enzyme-aristolochic acid molecular interactions
Cancerogenic and nephrotoxic aristolochic acids are activated by human cytochromes P450 1A1 and 1A: study on enzyme-aristolochic acid molecular interactions......
CE - Biochemie
- 2002 •
- D
Rok uplatnění
D - Stať ve sborníku
Human enzymes involved in metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2
Carcinogenic and nephrotoxic aristolochic acids are reduced by cytochromes P450 1A1 and 1A2 to specie binding to DNA......
CE - Biochemie
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy (AAN-DNA adduct formation was incre...
Biochemistry and molecular biology
- 2021 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid...
CE - Biochemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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