Filters
Show more
Show more
Show more
Show more
Show more
Show more
Show more
More filters
Results
A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid is detoxified by cytochrome P450 (CYP)-mediated O-demethylation to 8-hydroxyaristolochic acid
CE - Biochemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver
importance. Therefore, the present study has been designed to evaluate the cytochrome P450(CYP)-mediated oxidative detoxification and reductive activation of AAIThe herbal drug aristolochic acid ...
CE - Biochemie
- 2011 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The Role of Cytochrome P450 Enzymes in Carcinogen Metabolism: Lessons Learned From Studies With Benzo[a]pyrene and Aristolochic Acid
carcinogens, benzo[a]pyrene (BP) and aristolochic acid I (AAI). This chapter focuses detoxification metabolite aristolochic acid Ia [AAIa]) and reductively (to be activated of cytochrome...
Biochemistry and molecular biology
- 2018 •
- C •
- Link
Rok uplatnění
C - Kapitola v odborné knize
Výsledek na webu
Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo
Aristolochic acid I (AAI) is a natural plant alkaloid causing aristolochic acid activated or oxidatively detoxified to 8-hydroxyaristolochic acid (AAIa) by microsomal cytochrome P450<...
CE - Biochemie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen
Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans....
CE - Biochemie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Human enzymes involved in metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2
Carcinogenic and nephrotoxic aristolochic acids are reduced by cytochromes P450 1A1 and 1A2 to specie binding to DNA......
CE - Biochemie
- 2001 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Cancerogenic and nephrotoxic aristolochic acids are activated by human cytochromes P450 1A1 and 1A: study on enzyme-aristolochic acid molecular interactions
Cancerogenic and nephrotoxic aristolochic acids are activated by human cytochromes P450 1A1 and 1A: study on enzyme-aristolochic acid molecular interactions......
CE - Biochemie
- 2002 •
- D
Rok uplatnění
D - Stať ve sborníku
Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1
he herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid nephropathy (AAN), Balkan endemic importance. Human cytochrome P450 (CYP...
CE - Biochemie
- 2012 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy.
Aristolactam I is a detoxication metabolite of carcinogenic alkaloid aristolochic acid I. After activation of this metabolite by peroxidase and cytochrome P450 the DNA adduts are formed....
CE - Biochemie
- 1999 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid...
CE - Biochemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
- 1 - 10 out of 84 180